NBR1 Antibody - BSA Free

Manufactured by Genomic Antibody Technology™. GAT FAQs

NBR1 (Next to BRCA1 gene 1) is a protein which is ubiquitously expressed and highly conserved in eukaryotic organisms. NBR1 is implicated in TITIN kinase signaling in muscles and mitigates FGFR signaling through NBR1- SPRED2 interactions. Animals expressing truncated NBR1 lacking the C-terminal region has been shown to develop excessive bone mass due to increased activity of osteoblasts, suggesting NBR1's role in modulating bone metabolism in vivo. NBR1 functions as a negative regulator of p38 MAPK activity and has also been discovered as a binding partner of ATG8 family members including LC3, GABARAP, GABARAP-like 1/GABARAPL1, and GATE-16/GABARAPL2 in mammalian cells wherein these proteins are known to play essential role in formation of autophagosomes. Moreover, NBR1 interacts with ubiquitin/ubiquitinated proteins via ubiquitin-associated (UBA) domain and also interacts with TRIM55, SQSTM1, RNF29, USP8 etc. Based on these properties, it has been proposed that NBR1 functions as a cargo adapter for autophagic degradation of ubiquitinated substrates in a similar way to p62.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: ICC/IF, WB.

Showing Publications 1 - 8 of 8.

Publications using NBP1-71703	Applications	Species
VAmos, A;Shaw, A;Varga, K;CsomOs, I;MocsAr, G;Balajthy, Z;LAnyi, C;Bacso, Z;SzatmAri-TOth, M;KristOf, E; Mitophagy Mediates the Beige to White Transition of Human Primary Subcutaneous Adipocytes Ex Vivo Pharmaceuticals (Basel, Switzerland) [PMID: 35337160]
Kim MJ, Hwang GY, Cho MJ et al. Depletion of NBR1 in urothelial carcinoma cells enhances rapamycin-induced apoptosis through impaired autophagy and mitochondrial dysfunction J. Cell. Biochem. 2019-07-11 [PMID: 31297862]
Di Rienzo M, Antonioli M, Fusco C et al. Autophagy induction in atrophic muscle cells requires ULK1 activation by TRIM32 through unanchored K63-linked polyubiquitin chains Sci Adv 2019-05-01 [PMID: 31123703] (WB, Mouse)	WB	Mouse
Romagnoli A, Petruccioli E, Palucci I et al. Clinical isolates of the modern Mycobacterium tuberculosis lineage 4 evade host defense in human macrophages through eluding IL-1B-induced autophagy Cell Death Dis 2018-05-24 [PMID: 29795378] (ICC/IF, Human)	ICC/IF	Human
Kenific CM, Stehbens SJ, Goldsmith J et al. NBR1 enables autophagy-dependent focal adhesion turnover. J Cell Biol 2016-02-22 [PMID: 26903539] (ICC/IF, Human)	ICC/IF	Human
Murrow L, Malhotra R, Debnath J. ATG12-ATG3 interacts with Alix to promote basal autophagic flux and late endosome function Nat. Cell Biol. 2015-03-01 [PMID: 25686249] (WB)	WB
Malhotra R, Warne JP, Salas E et al. Loss of Atg12, but not Atg5, in pro-opiomelanocortin neurons exacerbates diet-induced obesity Autophagy. 2015-01-13 [PMID: 25585051] (WB)	WB
Cullup T, Kho AL, Dionisi-Vici C et al. Recessive mutations in EPG5 cause Vici syndrome, a multisystem disorder with defective autophagy Nat Genet 2012-12-09 [PMID: 23222957] (ICC/IF, Human)	ICC/IF	Human

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Verified Customer	ELISA	Human	12/05/2019	View Summary Application ELISA Sample Tested THP-1 macrophage lysate Species Human Lot A-2
Enlarge	3 reviewed by: Liu Yue	WB	Human and Mouse	07/14/2017	View Summary Application Western Blot Sample Tested hela cell,Mouse brain Species Human and Mouse Lot A-1

Array NBP1-71703

• NBR1 Antibodies
• NBR1 Lysates
• NBR1 Proteins