Mouse alpha-Fetoprotein/AFP Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

alpha-Fetoprotein (AFP), is albuminoid superfamily protein that is synthesized in the fetus primarily by the liver, yolk sac, and tissues of gastrointestinal origin. It is one of the earliest markers of the hepatocyte lineage. AFP acts as a carrier protein for steroids, bilirubin, fatty acids, retinoids, and flavonoids. In addition, it can exert immunosuppressive activity, regulate cell proliferation and apoptosis, initiate intracellular signaling, and contribute to cell invasion. Altered levels of both fetal and maternal AFP have been associated with hypothyroidism, autoimmune disorders, and heart defects. Low maternal serum AFP levels are associated with a higher incidence of Down syndrome, whereas higher levels are associated with spina bifida and anencephaly. Elevated AFP levels are also coincident with liver, stomach, and germ cell cancers.

We have publications tested in 2 confirmed species: Mouse, Transgenic Hamster.

Showing Publications 1 - 10 of 15. Show All 15 Publications. Collapse Publications.

Publications using MAFP00	Applications	Species
Chung, JY;Lee, W;Lee, OW;Ylaya, K;Nambiar, D;Sheehan-Klenk, J;Fayn, S;Hewitt, SM;Choyke, PL;Escorcia, FE; Glypican-3 deficiency in liver cancer upregulates MAPK/ERK pathway but decreases cell proliferation American journal of cancer research 2024-07-15 [PMID: 39113871] (Mouse)		Mouse
Schmithals, C;Kakoschky, B;Denk, D;von Harten, M;Klug, JH;Hintermann, E;Dropmann, A;Hamza, E;Jacomin, AC;Marquardt, JU;Zeuzem, S;Schirmacher, P;Herrmann, E;Christen, U;Vogl, TJ;Waidmann, O;Dooley, S;Finkelmeier, F;Piiper, A; Tumour-specific activation of a tumour-blood transport improves the diagnostic accuracy of blood tumour markers in mice EBioMedicine 2024-06-17 [PMID: 38889481] (Mouse)		Mouse
Zhang, Y;Liu, X;Sun, K;Luo, Y;Yang, J;Li, A;Kiupel, M;Fenske, S;Biel, M;Mi, QS;Wang, H;Xiao, H; Hyperpolarization-activated cyclic nucleotide-gated cation channel 3 promotes HCC development in a female-biased manner Cell reports 2023-09-20 [PMID: 37733590] (Mouse)		Mouse
Gerardo-Ram�rez, M;Giam, V;Becker, D;Groth, M;Hartmann, N;Morrison, H;May-Simera, HL;Radsak, MP;Marquardt, JU;Galle, PR;Herrlich, P;Straub, BK;Hartmann, M; Deletion of Cd44 Inhibits Metastasis Formation of Liver Cancer in Nf2-Mutant Mice Cells 2023-04-26 [PMID: 37174657] (Mouse)		Mouse
SR Giri, B Bhoi, C Trivedi, A Rath, R Rathod, A Sharma, R Ranvir, S Kadam, K Ingale, H Patel, A Nyska, MR Jain Saroglitazar suppresses the hepatocellular carcinoma induced by intraperitoneal injection of diethylnitrosamine in C57BL/6 mice fed on choline deficient, l-amino acid- defined, high-fat diet BMC Cancer, 2023-01-17;23(1):59. 2023-01-17 [PMID: 36650455] (Mouse)		Mouse
EE Abd El-Fat, S Saber, ME Youssef, H Eissa, E El-Ahwany, NA Amin, M Alqarni, GE Batiha, AJ Obaidullah, MMY Kaddah, AG Ahmed Gaaf, AAE Mourad, G Mostafa-He, AM Abdelhamid AKT-AMPKalpha-mTOR-dependent HIF-1alpha Activation is a New Therapeutic Target for Cancer Treatment: A Novel Approach to Repositioning the Antidiabetic Drug Sitagliptin for the Management of Hepatocellular Carcinoma Frontiers in Pharmacology, 2022-01-12;12(0):720173. 2022-01-12 [PMID: 35095479] (Mouse)		Mouse
A Deust, MN Chobert, V Demontant, G Gricourt, T Denaës, A Thiolat, I Ruiz, C Rodriguez, JM Pawlotsky, F Teixeira-C Macrophage autophagy protects against hepatocellular carcinogenesis in mice Scientific Reports, 2021-09-22;11(1):18809. 2021-09-22 [PMID: 34552122] (Mouse)		Mouse
E Di Giorgio, L Wang, Y Xiong, T Akimova, LM Christense, R Han, A Samanta, M Trevisanut, TR Bhatti, UH Beier, WW Hancock Mef2d sustains activation of effector Foxp3+ Tregs during transplant survival and anticancer immunity J. Clin. Invest., 2020-12-01;0(0):. 2020-12-01 [PMID: 32790649] (Mouse)		Mouse
RB Damgaard, HE Jolin, MED Allison, SE Davies, HL Titheradge, ANJ McKenzie, D Komander OTULIN protects the liver against cell death, inflammation, fibrosis, and cancer Cell Death Differ., 2020-03-30;27(5):1457-1474. 2020-03-30 [PMID: 32231246] (Mouse)		Mouse
K Matsuura, T Takami, M Maeda, T Hisanaga, K Fujisawa, I Saeki, T Matsumoto, I Hidaka, N Yamamoto, I Sakaida Evaluation of the Effects of Cultured Bone Marrow Mesenchymal Stem Cell Infusion on Hepatocarcinogenesis in Hepatocarcinogenic Mice With Liver Cirrhosis Transplant. Proc., 2019-04-01;51(3):925-935. 2019-04-01 [PMID: 30979485] (Mouse)		Mouse
PH Jaïs, E Decroly, E Jacquet, M Le Boulch, A Jaïs, O Jean-Jean, H Eaton, P Ponien, F Verdier, B Canard, S Goncalves, S Chiron, M Le Gall, P Mayeux, M Shmulevitz C3P3-G1: first generation of a eukaryotic artificial cytoplasmic expression system Nucleic Acids Res., 2019-03-18;0(0):. 2019-03-18 [PMID: 30726994] (Transgenic Hamster)		Transgenic Hamster
CC Fang, CF Wu, YJ Liao, SF Huang, M Chen, YA Chen AAV serotype 8-mediated liver specific GNMT expression delays progression of hepatocellular carcinoma and prevents carbon tetrachloride-induced liver damage Sci Rep, 2018-09-14;8(1):13802. 2018-09-14 [PMID: 30217986] (Mouse)		Mouse
G Cui, RC Martin, H Jin, X Liu, H Pandit, H Zhao, L Cai, P Zhang, W Li, Y Li Up-regulation of FGF15/19 signaling promotes hepatocellular carcinoma in the background of fatty liver J. Exp. Clin. Cancer Res., 2018-07-04;37(1):136. 2018-07-04 [PMID: 29973237] (Mouse)		Mouse
G Singhal, G Kumar, S Chan, FM Fisher, Y Ma, HG Vardeh, IA Nasser, JS Flier, E Maratos-Fl Deficiency of fibroblast growth factor 21 (FGF21) promotes hepatocellular carcinoma (HCC) in mice on a long term obesogenic diet Mol Metab, 2018-03-08;0(0):. 2018-03-08 [PMID: 29753678] (Mouse)		Mouse
A Ambade, A Satishchan, B Gyongyosi, P Lowe, G Szabo Adult mouse model of early hepatocellular carcinoma promoted by alcoholic liver disease World J Gastroenterol, 2016-04-28;22(16):4091-108. 2016-04-28 [PMID: 27122661] (Mouse)		Mouse
Show All 15 Publications. Collapse Publications.

Array MAFP00

• alpha-Fetoprotein/AFP Antibodies
• alpha-Fetoprotein/AFP Antibody Pair
• alpha-Fetoprotein/AFP ELISA Kits
• alpha-Fetoprotein/AFP Lysate
• alpha-Fetoprotein/AFP Proteins
• alpha-Fetoprotein/AFP ELISAs