Cytokeratin 19 Antibody - BSA Free

Cytokeratin 19 (KRT19) is an intermediate filament (IF) protein that is part of the Keratin family of proteins. This protein is also known by the names of Keratin 19 or Keratin type I Cytoskeletal 19. The Keratin family consists of Keratin 1-20, which are divided into two subtypes: Type 1 contains the acidic Cytokeratin proteins consisting of Cytokeratins 9-20, including KRT19; Type 2 Keratins include the basic to neutral protein and contains Cytokeratin 1-8. Type 1 and Type 2 Keratins often form oligomers, interacting to create heterotypic chains. However, KRT19 is unique in that while being the smallest of the Type 1 Keratin proteins, it does not interact with any Type 2 Keratins. IF proteins such as KRT19 are integral for defining and maintaining cellular structure and morphology, and are important for cellular integrity by anchoring to membrane complexes via proteins such as Epiplakin, Trichoplein, Periplakin, Plakophilins, Plectin, BPAG1, Desmoplakin, and Envoplakin. KRT19 is also involved in the organization of the myofibers of striated muscle. KRT19 and other Cytokeratin proteins are mainly found in epithelial cells, with KRT19 being expressed exclusively in defined zones of basal keratinocytes. KRT19 is an important biomarker for breast cancer cells, tumor cells of the lymph nodes, peripheral blood, and bone marrow. Cytokeratin 19 can be expressed with KRT8 and KRT18 to differentiate cells of epithelial lines from hematopoietic tumor cells in the peripheral blood.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 7 applications: ICC/IF, IF/IHC, IHC-Fr, IHC-P, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, WB.

Showing Publications 1 - 10 of 10.

Publications using NB100-687	Applications	Species
Zhang C, Zhong L, Lau Y et al. Single Cell RNA Sequencing Reveals Emergent Notochord-Derived Cell Subpopulations in the Postnatal Nucleus Pulposus bioRxiv 2023-05-23 [PMID: 37292597] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Serra M, Pal R, Puliga E et al. mRNA-miRNA networks identify metabolic pathways associated to the anti-tumorigenic effect of thyroid hormone on preneoplastic nodules and hepatocellular carcinoma Frontiers in Oncology 2022-09-20 [PMID: 36203462] (Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen)	Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen
Barthet VJA, Brucoli M, Ladds MJGW et al. Autophagy suppresses the formation of hepatocyte-derived cancer-initiating ductular progenitor cells in the liver Science advances 2021-06-01 [PMID: 34088666] (IHC-P, Mouse)	IHC-P	Mouse
OrrU C, Perra A, Kowalik MA et al. Distinct Mechanisms Are Responsible for Nrf2-Keap1 Pathway Activation at Different Stages of Rat Hepatocarcinogenesis Cancers (Basel) 2020-08-16 [PMID: 32824383] (IF/IHC, Rat)	IF/IHC	Rat
Kim N, Kim HK, Lee K et al. Single-cell RNA sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma Nat Commun 2020-05-08 [PMID: 32385277] (IHC-P, Human)	IHC-P	Human
Loforese G, Malinka T, Keogh A et al. Impaired liver regeneration in aged mice can be rescued by silencing Hippo core kinases MST1 and MST2. EMBO Mol Med. 2016-12-09 [PMID: 27940445] (ICC/IF, WB, Mouse)	ICC/IF, WB	Mouse
Natalia Lugli, Irene Kamileri, Adrian Keogh, Thomas Malinka, Michalis E Sarris, Iannis Talianidis, Olivier Schaad, Daniel Candinas, Deborah Stroka, Thanos D Halazonetis R‐spondin 1 and noggin facilitate expansion of resident stem cells from non‐damaged gallbladders EMBO Reports 2016-03-18 [PMID: 26993089]
Sawitza I, Kordes C, Gotze S et al. Bile acids induce hepatic differentiation of mesenchymal stem cells. Sci Rep 2015-08-25 [PMID: 26304833] (ICC/IF, Rat)	ICC/IF	Rat
Kordes C, Sawitza I, Gotze S et al. Hepatic stellate cells contribute to progenitor cells and liver regeneration. J. Clin. Invest. 2014-12-01 [PMID: 25401473] (IF/IHC, Rat)	IF/IHC	Rat
Takeda K, Kojima Y, Ikejima K et al. Death receptor 5 mediated-apoptosis contributes to cholestatic liver disease. PNAS;105(31):10895-10900. 2008-01-01 [PMID: 18667695] (IF/IHC, Mouse)	IF/IHC	Mouse

Images	Ratings	Applications	Species	Date	Details
	3 reviewed by: Verified Customer	IHC-P	Mouse	03/04/2009	View Summary Application Immunohistochemistry-Paraffin Sample Tested Mouse Tissue Sections - Liver Species Mouse Lot 1174

Array NB100-687

• Cytokeratin 19 Antibodies
• Cytokeratin 19 ELISA Kit
• Cytokeratin 19 Lysate
• Cytokeratin 19 Proteins