Mitofusin 2 Antibody (6A8)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: IF/IHC.

Showing Publications 1 - 10 of 15. Show All 15 Publications. Collapse Publications.

Publications using H00009927-M01	Applications	Species
Jason V, Edwin C Mitofusin 2 sustains the axonal mitochondrial network to support presynaptic Ca2+ homeostasis and the synaptic vesicle cycle in rat hippocampal axons. J Neurosci. 2023-03-30 [PMID: 36997314]
Andres V, Alfredo G, Javier D et al. The smoothened agonist SAG reduces mitochondrial dysfunction and neurotoxicity of frataxin-deficient astrocytes. J Neuroinflammation. 2022-04-12 [PMID: 35413853]
Bharat V, Hsieh CH, Wang X Mitochondrial Defects in Fibroblasts of Pathogenic MAPT Patients Frontiers in cell and developmental biology 2021-11-03 [PMID: 34805172]
Serena A, Valentina D, Mario F et al. Drug repositioning as a therapeutic strategy for neurodegenerations associated with OPA1 mutations. Hum Mol Genet. 2021-01-21 [PMID: 33231680]
Irene L, Christian B, Marco B et al. Coenzyme Q biosynthesis inhibition induces HIF-1? stabilization and metabolic switch toward glycolysis. FEBS J. 2020-09-20 [PMID: 32898935]
Maresca A, Del V, Capristo M et al. DNMT1 mutations leading to neurodegeneration paradoxically reflect on mitochondrial metabolism. Hum Mol Genet. 2020-01-27 [PMID: 31984424]
Malek K, Jerome P, Lydie N et al. Novel role of Tieg1 in muscle metabolism and mitochondrial oxidative capacities. Acta Physiol (Oxf). 2019-10-19 [PMID: 31560161]
Zhao Y, Sun X, Hu D et al. ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects. Nat Commun. 2019-03-26 [PMID: 30914652]
Ferreira JCB, Campos JC, Qvit N et al. A selective inhibitor of mitofusin 1-beta IIPKC association improves heart failure outcome in rats. Nat Commun. 2019-04-09 [PMID: 30659190]
Del V, Fogazza M, Musiani F et al. Deciphering OPA1 mutations pathogenicity by combined analysis of human, mouse and yeast cell models. Biochim Biophys Acta Mol Basis Dis. 2018-08-04 [PMID: 30293569]
Sacks J, Mulya A, Fealy CE et al. Effect of Roux-en-Y gastric bypass on liver mitochondrial dynamics in a rat model of obesity. Physiol Rep 2018-01-09 [PMID: 29464885]
Mattie S, Riemer J, Wideman JG et al. A new mitofusin topology places the redox-regulated C terminus in the mitochondrial intermembrane space. J Cell Biol 2017-12-06 [PMID: 29212658]
Cormio A, Musicco C, Gasparre G et al. Increase in proteins involved in mitochondrial fission, mitophagy, proteolysis and antioxidant response in type I endometrial cancer as an adaptive response to respiratory complex I deficiency. Biochem Biophys Res Commun 2017-07-08 [PMID: 28698145]
Stacchiotti Alessandra, Favero Gaia, Giugno Lorena et al. Mitochondrial and metabolic dysfunction in renal convoluted tubules of obese mice: protective role of melatonin. PLoS One. 2014-10-27 [PMID: 25347680] (IF/IHC, Mouse)	IF/IHC	Mouse
Show All 15 Publications. Collapse Publications.

Array H00009927-M01

• Mitofusin 2 Antibodies
• Mitofusin 2 Lysates
• Mitofusin 2 Proteins