I am about to study the expression of MGP in valvular tissue. This protein is a vitamin K dependent BMP2 inhibitor and protect from calcification. The protein is gamma-carboxylated by vitamin K and the literature reports ELISA assays on dp-cMGP (carboxylated) and dp-ucMGP (uncarboxylated). Do you know which form (carb or uncarb) is recognized by this antibody? Also, are you aware of the availability of an antibody to detect the uncarboxylated form in IHC-P?

Name: MGP Antibody
Brand: Novus Biologicals
SKU: NBP1-86465
Price: 519 USD

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Accepted Answer

Our MGP antibody with catalogue number NBP1-86465 was generated against a recombinant protein corresponding to amino acids 24-97 of the human protein. Unfortunately we do not have any testing data which shows whether this antibody is specific to a carboxylated or decarboxylated form of the protein. I am sorry for any inconvenience.

At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	HuSpecies Glossary
Applications	IHC
Clonality	Polyclonal
Host	Rabbit
Conjugate	Unconjugated

Immunogen	This antibody was developed against Recombinant Protein corresponding to amino acids: ESMESYELNPFINRRNANTFISPQQRWRAKVQERIRERSKPVHELNREACDDYRLCERYAMVYGYNAAYNRYFR
Isotype	IgG
Clonality	Polyclonal
Host	Rabbit
Gene	MGP
Purity	Immunogen affinity purified
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer	PBS (pH 7.2) and 40% Glycerol
Preservative	0.02% Sodium Azide
Purity	Immunogen affinity purified

Publications using NBP1-86465	Applications	Species
Zhang Y, Han S, Kong M Et Al. Single-cell RNA-seq analysis identifies unique chondrocyte subsets and reveals involvement of ferroptosis in human intervertebral disc degeneration Osteoarthritis and cartilage 2021-07-06 [PMID: 34242803] (IHC-P)	IHC-P
Lorenzen JM, Martino F, Scheffner I et al. Fetuin, Matrix-Gla Protein and Osteopontin in Calcification of Renal Allografts. PLoS One 2012-01-01 [PMID: 23284864]

MGP Antibody

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