MED13 Antibody

This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene is proposed to form a sub-complex with MED12, cyclin C, and CDK8 that can negatively regulate transactivation by mediator.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Primate.

We have publications tested in 1 application: WB.

Showing Publications 1 - 3 of 3.

Publications using NB100-60642	Applications	Species
Roliński M, Montaldo NP, Aksu ME, et al. Loss of Mediator complex subunit 13 (MED13) promotes resistance to alkylation through cyclin D1 upregulation Nucleic acids research 2021-01-14 [PMID: 33444446] (WB, Human)	WB	Human
Wagner LM, Deluca NA Temporal Association of Herpes Simplex Virus ICP4 with Cellular Complexes Functioning at Multiple Steps in PolII Transcription PLoS One 2013-10-11 [PMID: 24147125] (WB, Primate) Details: Chlorocebus pygerythrus (Vervet monkey)	WB	Primate
Knuesel MT, Meyer KD, Donner AJ et al. The human CDK8 subcomplex is a histone kinase that requires Med12 for activity and can function independently of mediator. Mol Cell Biol 2009-02-01 [PMID: 19047373]

Array NB100-60642

• MED13 Antibodies
• MED13 Protein