LIF Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

LIF (Leukemia inhibitory factor; also  Differentiation-stimulating factor) is a 22 kDa (predicted) glycoprotein, member of  the leukemia inhibitory factor/interleukin-6 (LIF/IL-6) family of cytokines. Natural LIF is heavily glycosylated, showing an apparent molecular weight of 32 kDa to 62 kDa, it is produced by a variety of cells including T cells, monocytes, fibroblasts, osteoblasts and mast cells. LIF induces hematopoietic differentiation in normal and myeloid leukemia cells, neuronal cell differentiation and stimulation of acute-phase protein synthesis in hepatocytes. Human LIF acts through a receptor comprising a 190 kDa LIF-binding alpha -chain and a 130 kDa signal-transducing beta -chain (gp130), which is shared with the other members of the IL-6 family. Human and mouse LIF exhibit 78% aa sequence identity.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Primate - Macaca mulatta (Rhesus Macaque).

We have publications tested in 5 applications: ICC, IHC, IHC-P, Neutralization, Western Blot.

Showing Publications 1 - 10 of 17. Show All 17 Publications. Collapse Publications.

Publications using AF-250-NA	Applications	Species
X Yue, J Wang, CY Chang, J Liu, X Yang, F Zhou, X Qiu, V Bhatt, JY Guo, X Su, L Zhang, Z Feng, W Hu Leukemia inhibitory factor drives glucose metabolic reprogramming to promote breast tumorigenesis Cell Death & Disease, 2022-04-19;13(4):370. 2022-04-19 [PMID: 35440095] (Neutralization, Human)	Neutralization	Human
M Kessler, K Hoffmann, K Fritsche, V Brinkmann, HJ Mollenkopf, O Thieck, AR Teixeira d, EI Braicu, J Sehouli, M Mangler, H Berger, TF Meyer Chronic Chlamydia infection in human organoids increases stemness and promotes age-dependent CpG methylation Nat Commun, 2019-03-18;10(1):1194. 2019-03-18 [PMID: 30886143] (Neutralization, Human)	Neutralization	Human
K McLean, L Tan, DE Bolland, LG Coffman, LF Peterson, M Talpaz, N Neamati, RJ Buckanovic Leukemia inhibitory factor functions in parallel with interleukin-6 to promote ovarian cancer growth Oncogene, 2018-10-10;0(0):. 10/10/2018 [PMID: 30305729]
JE Yoon, Y Kim, S Kwon, M Kim, YH Kim, JH Kim, TJ Park, HY Kang Senescent fibroblasts drive ageing pigmentation: ?A potential therapeutic target for senile lentigo Theranostics, 2018-09-09;8(17):4620-4632. 2018-09-09 [PMID: 30279727] (IHC-P, Human)	IHC-P	Human
F Wu, X Chen, Y Liu, B Liang, H Xu, TC Li, CC Wang Decreased MUC1 in endometrium is an independent receptivity marker in recurrent implantation failure during implantation window Reprod. Biol. Endocrinol., 2018-06-21;16(1):60. 2018-06-21 [PMID: 29929546] (IHC, Human)	IHC	Human
C Ueshima, TR Kataoka, M Hirata, A Sugimoto, Y Iemura, S Minamiguch, T Nomura, H Haga Possible involvement of human mast cells in the establishment of pregnancy via KIR2DL4 Am. J. Pathol., 2018-03-22;0(0):. 2018-03-22 [PMID: 29577936] (Neutralization, Human)	Neutralization	Human
Amy Winship, Jeanne Correia, Jian-Guo Zhang, Nicos A. Nicola, Evdokia Dimitriadis Leukemia Inhibitory Factor (LIF) Inhibition during Mid-Gestation Impairs Trophoblast Invasion and Spiral Artery Remodelling during Pregnancy in Mice PLOS ONE 2015-10-19 [PMID: 26479247]
Amy Winship, Jeanne Correia, Tara Krishnan, Ellen Menkhorst, Carly Cuman, Jian-Guo Zhang et al. Blocking Endogenous Leukemia Inhibitory Factor During Placental Development in Mice Leads to Abnormal Placentation and Pregnancy Loss Scientific Reports 2015-08-14 [PMID: 26272398]
Xiao Y, Sun X, Yang X, Zhang J, Xue Q, Cai B, Zhou Y Leukemia inhibitory factor is dysregulated in the endometrium and uterine flushing fluid of patients with adenomyosis during implantation window. Fertil. Steril., 2009-04-09;94(1):85-9. 2009-04-09 [PMID: 19361790] (IHC-P, Human)	IHC-P	Human
Aghajanova L, Altmae S, Bjuresten K, Hovatta O, Landgren BM, Stavreus-Evers A Disturbances in the LIF pathway in the endometrium among women with unexplained infertility. Fertil. Steril., 2008-08-05;91(6):2602-10. 2008-08-05 [PMID: 18684446] (IHC-P, Human)	IHC-P	Human
Meng CX, Andersson KL, Bentin-Ley U, Gemzell-Danielsson K, Lalitkumar PG Effect of levonorgestrel and mifepristone on endometrial receptivity markers in a three-dimensional human endometrial cell culture model. Fertil. Steril., 2008-01-18;91(1):256-64. 2008-01-18 [PMID: 18206148] (ICC, Human)	ICC	Human
Kamohara H, Ogawa M, Ishiko T, Sakamoto K, Baba H Leukemia inhibitory factor functions as a growth factor in pancreas carcinoma cells: Involvement of regulation of LIF and its receptor expression. Int. J. Oncol., 2007-04-01;30(4):977-83. 2007-04-01 [PMID: 17332938] (Neutralization, Human)	Neutralization	Human
Aghajanova L, Skottman H, Stromberg AM, Inzunza J, Lahesmaa R, Hovatta O Expression of leukemia inhibitory factor and its receptors is increased during differentiation of human embryonic stem cells. Fertil. Steril., 2006-09-01;86(4):1193-209. 2006-09-01 [PMID: 16949591] (ICC, Human)	ICC	Human
He W, Gong K, Smith DK, Ip NY The N-terminal cytokine binding domain of LIFR is required for CNTF binding and signaling. FEBS Lett., 2005-08-15;579(20):4317-23. 2005-08-15 [PMID: 16051226] (Western Blot, Human)	Western Blot	Human
Andersson By U, Tani E, Andersson U Tumor necrosis factor, interleukin 11, and leukemia inhibitory factor produced by Langerhans cells in Langerhans cell histiocytosis. J. Pediatr. Hematol. Oncol., 2004-11-01;26(11):706-11. 2004-11-01 [PMID: 15543003] (ICC, Human)	ICC	Human
Sengupta J, Dhawan L, Ghosh D Immunohistochemical localization of leukemia inhibitory factor, interleukins 1 and 6 at the primary implantation site in the rhesus monkey. Cytokine, 2003-12-21;24(6):277-85. 2003-12-21 [PMID: 14609569] (IHC-P, Primate - Macaca mulatta (Rhesus Macaque))	IHC-P	Primate - Macaca mulatta (Rhesus Macaque)
Ben-Shlomo A, Miklovsky I, Ren SG, Yong WH, Heaney AP, Culler MD, Melmed S Leukemia inhibitory factor regulates prolactin secretion in prolactinoma and lactotroph cells. J. Clin. Endocrinol. Metab., 2003-02-01;88(2):858-63. 2003-02-01 [PMID: 12574225] (IHC-P, Human)	IHC-P	Human
Show All 17 Publications. Collapse Publications.

Array AF-250-NA

• LIF Antibodies
• LIF ELISA Kit
• LIF Lysate
• LIF Proteins
• LIF ELISAs
• LIF Proteins and Enzymes