Human IL-11 Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interleukin-11, also known as AGIF, is a pleiotropic cytokine in the IL-6 family, which also includes LIF, CNTF, Oncostatin M, Cardiotrophin-1, IL-27, and IL-31. It is secreted by osteoblasts, synoviocytes, fibroblasts, chondrocytes, intestinal myofibroblasts, and trophoblasts. It is found in the plasma mainly during inflammation, and is considered to be primarily anti-inflammatory. It stimulates hematopoiesis and thrombopoiesis, regulates macrophage differentiation, and confers mucosal protection in the intestine. It has also been found to enhance T cell polarization toward Th2, promote B cell IgG production, increase osteoclast bone absorption, protect endothelial cells from oxidative stress, and regulate epithelial proliferation and apoptosis. IL-11 signals through a receptor complex that contains IL-11 R alpha and gp130. A soluble form of IL-11 R alpha can bind IL-11 and either form a signaling complex with gp130 on the cell surface or inhibit cell surface IL-11 R alpha/gp130 signaling.

We have publications tested in 2 confirmed species: Human, Mouse.

Showing Publications 1 - 10 of 30. Show All 30 Publications. Collapse Publications.

Publications using D1100	Applications	Species
Widjaja, AA;Lim, WW;Viswanathan, S;Chothani, S;Corden, B;Dasan, CM;Goh, JWT;Lim, R;Singh, BK;Tan, J;Pua, CJ;Lim, SY;Adami, E;Schafer, S;George, BL;Sweeney, M;Xie, C;Tripathi, M;Sims, NA;Hübner, N;Petretto, E;Withers, DJ;Ho, L;Gil, J;Carling, D;Cook, SA; Inhibition of IL-11 signalling extends mammalian healthspan and lifespan Nature 2024-07-17 [PMID: 39020175] (Human)		Human
AA Widjaja, S Viswanatha, SG Shekeran, E Adami, WW Lim, S Chothani, J Tan, JWT Goh, HM Chen, SY Lim, CM Boustany-K, J Hawkins, E Petretto, N Hübner, S Schafer, TM Coffman, SA Cook Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease Nature Communications, 2022-12-05;13(1):7497. 2022-12-05 [PMID: 36470928] (Human)		Human
Q Luo, J Liu, Q Fu, X Zhang, P Yu, P Liu, J Zhang, H Tian, S Chen, H Zhang, T Qin Identifying cancer cell-secreted proteins that activate cancer-associated fibroblasts as prognostic factors for patients with pancreatic cancer Journal of Cellular and Molecular Medicine, 2022-10-25;0(0):. 2022-10-25 [PMID: 36282889] (Human)		Human
A Gallo, N Cuscino, F Contino, M Bulati, M Pampalone, G Amico, G Zito, C Carcione, C Centi, A Bertani, PG Conaldi, V Miceli Changes in the Transcriptome Profiles of Human Amnion-Derived Mesenchymal Stromal/Stem Cells Induced by Three-Dimensional Culture: A Potential Priming Strategy to Improve Their Properties International Journal of Molecular Sciences, 2022-01-13;23(2):. 2022-01-13 [PMID: 35055049] (Human)		Human
AA Hastreiter, GG Dos Santos, EN Makiyama, EWC Santos, P Borelli, RA Fock Effects of protein malnutrition on haematopoietic regulatory activity of bone marrow mesenchymal stem cells The Journal of nutritional biochemistry, 2021-03-08;0(0):108626. 2021-03-08 [PMID: 33705953] (Mouse)		Mouse
L Panahipour, A Omerbasic, J Nasirzade, R Gruber TGF-&beta Activity of a Demineralized Bone Matrix International Journal of Molecular Sciences, 2021-01-11;22(2):. 2021-01-11 [PMID: 33440877] (Human)		Human
J Dong, S Viswanatha, E Adami, BK Singh, SP Chothani, B Ng, WW Lim, J Zhou, M Tripathi, NSJ Ko, SG Shekeran, J Tan, SY Lim, M Wang, PM Lio, PM Yen, S Schafer, SA Cook, AA Widjaja Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH Nature Communications, 2021-01-04;12(1):66. 2021-01-04 [PMID: 33397952] (Human)		Human
AM Gamage, KS Tan, WOY Chan, J Liu, CW Tan, YK Ong, M Thong, AK Andiappan, DE Anderson, Y Wang, LF Wang Infection of human Nasal Epithelial Cells with SARS-CoV-2 and a 382-nt deletion isolate lacking ORF8 reveals similar viral kinetics and host transcriptional profiles PloS Pathogens, 2020-12-07;16(12):e1009130. 2020-12-07 [PMID: 33284849] (Human)		Human
M Tylicka, E Matuszczak, A Hermanowic, W D?bek, M Karpi?ska, J Kami?ska, OM Koper-Lenk BDNF and IL-8, But Not UCHL-1 and IL-11, Are Markers of Brain Injury in Children Caused by Mild Head Trauma Brain sciences, 2020-09-24;10(10):. 2020-09-24 [PMID: 32987792] (Human)		Human
MT Agulló-Ort, Ó Gómez-Mart, S Ponce, L Iglesias, L Ojeda, I Ferrer, I García-Rui, L Paz-Ares, V Pardo-Marq Blood Predictive Biomarkers for Patients With Non-small-cell Lung Cancer Associated With Clinical Response to Nivolumab Clin Lung Cancer, 2019-08-30;0(0):. 2019-08-30 [PMID: 31562055] (Human)		Human
Z Chen, X Chen, R Xie, M Huang, W Dong, J Han, J Zhang, Q Zhou, H Li, J Huang, T Lin DANCR Promotes Metastasis and Proliferation in Bladder Cancer Cells by Enhancing IL-11-STAT3 Signaling and CCND1 Expression Mol. Ther., 2019-01-09;27(2):326-341. 2019-01-09 [PMID: 30660488] (Human)		Human
K Terawaki, Y Kashiwase, M Uzu, M Nonaka, Y Sawada, K Miyano, Y Higami, K Yanagihara, M Yamamoto, Y Uezono Leukemia inhibitory factor via the Toll-like receptor 5 signaling pathway involves aggravation of cachexia induced by human gastric cancer-derived 85As2 cells in rats Oncotarget, 2018-10-05;9(78):34748-34764. 2018-10-05 [PMID: 30410674] (Human)		Human
L Qian Decreased interleukin-11 levels in the semen of infertile males Cytokine, 2018-03-22;108(0):57-59. 2018-03-22 [PMID: 29573586] (Human)		Human
VO Lewis, E Devarajan, M Cardó-Vila, DG Thomas, ES Kleinerman, S Marchiò, RL Sidman, R Pasqualini, W Arap BMTP-11 is active in preclinical models of human osteosarcoma and a candidate targeted drug for clinical translation Proc. Natl. Acad. Sci. U.S.A., 2017-07-11;0(0):. 2017-07-11 [PMID: 28698375] (Human)		Human
Onnis , Barbara, Fer , Nicole, Rapisarda , Annamari, Perez , Victor S, Melillo , Giovanni Autocrine production of IL-11 mediates tumorigenicity in hypoxic cancer cells. J Clin Invest, 2013-03-15;123(4):1615-29. 2013-03-15 [PMID: 23549086] (Human)		Human
Rufo A, Del Fattore A, Capulli M, Carvello F, De Pasquale L, Ferrari S, Pierroz D, Morandi L, De Simone M, Rucci N, Bertini E, Bianchi ML, De Benedetti F, Teti A Mechanisms inducing low bone density in duchenne muscular dystrophy in mice and humans. J. Bone Miner. Res., 2011-08-01;26(8):1891-903. 2011-08-01 [PMID: 21509823] (Human)		Human
Jung Y, Ahn H, Kim DS, Hwang YR, Ho SH, Kim JM, Kim S, Ma S, Kim S Improvement of biological and pharmacokinetic features of human interleukin-11 by site-directed mutagenesis. Biochem. Biophys. Res. Commun., 2011-01-14;405(3):399-404. 2011-01-14 [PMID: 21238428] (Human, Mouse)		Human, Mouse
Yang L, Wang L, Zhao CH, Zhu XJ, Hou Y, Jun P, Hou M Contributions of TRAIL-mediated megakaryocyte apoptosis to impaired megakaryocyte and platelet production in immune thrombocytopenia. Blood, 2010-07-29;116(20):4307-16. 2010-07-29 [PMID: 20671119] (Human)		Human
Liem-Moolenaar M, Cerneus D, Molloy C, End D, Brown K, de Kam M, Cohen A, van Hensbergen Y, Burggraaf J Pharmacodynamics and Pharmacokinetics of the Novel Thrombopoietin Mimetic Peptide RWJ-800088 in Humans. 2008-10-01;84(0):481. 2008-10-01 [PMID: 19238653] (Human)		Human
Bronte-Tinkew DM, Terebiznik M, Franco A, Ang M, Ahn D, Mimuro H, Sasakawa C, Ropeleski MJ, Peek RM, Jones NL Helicobacter pylori cytotoxin-associated gene A activates the signal transducer and activator of transcription 3 pathway in vitro and in vivo. Cancer Res., 2009-01-15;69(2):632-9. 2009-01-15 [PMID: 19147578] (Human)		Human
Zdzisinska B, Bojarska-Junak A, Dmoszynska A, Kandefer-Szerszen M Abnormal cytokine production by bone marrow stromal cells of multiple myeloma patients in response to RPMI8226 myeloma cells. Arch. Immunol. Ther. Exp. (Warsz.), 2008-05-30;56(3):207-21. 2008-05-30 [PMID: 18512025] (Human)		Human
Siddappa R, Martens A, Doorn J, Leusink A, Olivo C, Licht R, van Rijn L, Gaspar C, Fodde R, Janssen F, van Blitterswijk C, de Boer J cAMP/PKA pathway activation in human mesenchymal stem cells in vitro results in robust bone formation in vivo. Proc. Natl. Acad. Sci. U.S.A., 2008-05-19;105(20):7281-6. 2008-05-19 [PMID: 18490653] (Human)		Human
Zhang Y, Taveggia C, Melendez-Vasquez C, Einheber S, Raine CS, Salzer JL, Brosnan CF, John GR Interleukin-11 potentiates oligodendrocyte survival and maturation, and myelin formation. J. Neurosci., 2006-11-22;26(47):12174-85. 2006-11-22 [PMID: 17122042] (Human)		Human
Vergne-Salle</LastName><F P</Initial, Vergne-Salle P, Leger DY, Bertin P, Treves R, Beneytout JL, Liagre B Effects of the active metabolite of leflunomide, A77 1726, on cytokine release and the MAPK signalling pathway in human rheumatoid arthritis synoviocytes. Cytokine, 2005-09-07;31(5):335-48. 2005-09-07 [PMID: 16099671] (Human)		Human
Chung HL, Kim WT, Kim JK, Choi EJ, Lee JH, Lee GH, Kim SG Relationship between atopic status and nasal interleukin 10 and 11 levels in infants with respiratory syncytial virus bronchiolitis. Ann. Allergy Asthma Immunol., 2005-02-01;94(2):267-72. 2005-02-01 [PMID: 15765744] (Human)		Human
Hirota H, Izumi M, Hamaguchi T, Sugiyama S, Murakami E, Kunisada K, Fujio Y, Oshima Y, Nakaoka Y, Yamauchi-Takihara K Circulating interleukin-6 family cytokines and their receptors in patients with congestive heart failure. Heart Vessels, 2004-09-01;19(5):237-41. 2004-09-01 [PMID: 15372299] (Human)		Human
Lopez-Karpovitch X, Barrales-Benitez O, Flores M, Piedras J Effect of azacytidine in the release of leukemia inhibitory factor, oncostatin m, interleukin (IL)-6, and IL-11 by mononuclear cells of patients with refractory anemia. Cytokine, 2002-11-24;20(4):154-62. 2002-11-24 [PMID: 12543079] (Human)		Human
Dimitriadis E, Robb L, Salamonsen LA Interleukin 11 advances progesterone-induced decidualization of human endometrial stromal cells. Mol. Hum. Reprod., 2002-07-01;8(7):636-43. 2002-07-01 [PMID: 12087078] (Human)		Human
Carstanjen D, Regenfus M, Muller C, Salama A Interleukin-6 is a major effector molecule of short-term G-CSF treatment inducing bone metabolism and an acute-phase response. Exp. Hematol., 2001-07-01;29(7):812-21. 2001-07-01 [PMID: 11438203] (Human)		Human
Curti A, Ratta M, Corinti S, Girolomoni G, Ricci F, Tazzari P, Siena M, Grande A, Fogli M, Tura S, Lemoli RM Interleukin-11 induces Th2 polarization of human CD4(+) T cells. Blood, 2001-05-01;97(9):2758-63. 2001-05-01 [PMID: 11313268] (Human)		Human
Show All 30 Publications. Collapse Publications.

Array D1100

• IL-11 Antibodies
• IL-11 ELISA Kits
• IL-11 Lysate
• IL-11 Proteins
• IL-11 Proteins and Enzymes
• IL-11 ELISAs