LIF Antibody [Biotin]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

LIF is a 36‑67 kDa highly glycosylated polypeptide (1, 2) produced by a variety of cells including T cells (3), monocytes (4), fibroblasts (5), osteoblasts (6) and mast cells (7). Consistent with its many synonyms, LIF exhibits a broad spectrum of effects on both hematopoietic and nonhematopoietic cells. For example, LIF inhibits the differentiation of embryonic stem cells (8), up regulates the synthesis of acute phase proteins in hepatocytes (9), down regulates lipoprotein lipase activity in adipocytes (10), and preferentially induces a cholinergic phenotype in sympathetic neurons (11). The receptor for LIF (LIF R) has been isolated and found to be a 190 kDa type I transmembrane glycoprotein (12). Although this molecule binds LIF, the resultant LIF-LIF R complex is not sufficient to transduce an intracellular signal. This capability is provided by a 130 kDa signal transducing subunit (gp130) that is common to the functional receptors for IL-6, IL-11, CNTF, and Oncostatin M (13, 14). Since gp130 is a ubiquitously expressed membrane protein, the presence of LIF R (membrane-bound or soluble form) ultimately determines the cell’s responsiveness to LIF. Cells known to express LIF R include osteoblasts (6), hepatocytes (15), macrophages (15), neurons (5), and megakaryocytes (16). Human and mouse LIF exhibit 78% sequence homology, and human LIF is biologically active on mouse cells.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: ELISA Development.

Showing Publications 1 - 4 of 4.

Publications using BAF250	Applications	Species
Tohru Yarimizu, Mikiko Nakamura, Hisashi Hoshida, Rinji Akada Synthetic signal sequences that enable efficient secretory protein production in the yeast Kluyveromyces marxianus Microbial Cell Factories 12/1/2015 [PMID: 25889890]
Singh AP, Archer TK. Analysis of the SWI/SNF chromatin-remodeling complex during early heart development and BAF250a repression cardiac gene transcription during P19 cell differentiation. Nucleic Acids Res 3/1/2014 [PMID: 24335282]
Eriko Simamura, Hiroki Shimada, Nobuaki Higashi, Maimi Uchishiba, Hiroki Otani, Toshihisa Hatta Maternal Leukemia Inhibitory Factor (LIF) Promotes Fetal Neurogenesis via a LIF-ACTH-LIF Signaling Relay Pathway Endocrinology 4/1/2010 [PMID: 20160138]
Hess S, 2019, Rheinheimer C, Tidow F, Bartling G, Kaps C, Lauber J, Buer J, Klos A The reprogrammed host: Chlamydia trachomatis-induced up-regulation of glycoprotein 130 cytokines, transcription factors, and antiapoptotic genes. 7046, 2001-10-01;44(10):2392-401. 2001-10-01 [PMID: 11665982] (ELISA Development, Human)	ELISA Development	Human

Array BAF250

• LIF Antibodies
• LIF ELISA Kit
• LIF Lysate
• LIF Proteins
• LIF Proteins and Enzymes
• LIF ELISAs