LAT Antibody (661002) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

LAT (Linker for activation of T cells; also pp36) is a 36-38 kDa type III (no signal sequence; extracellular N-terminus) transmembrane adaptor phosphoprotein. It is expressed on mast cells, NK cells, monocytes (but not macrophages), platelets and T cells. LAT is phosphorylated upon ligation of the TCR, GPVI, and Fc epsilon RI, and serves as an anchor for several SH2-domain containing signaling proteins, including PLCg1, SLP76 and Grb2. Human LAT is 262 amino acids (aa) in length. It contains a four aa extracellular segment with a 235 aa cytoplasmic domain (aa 28-262). Palmitoylation occurs on Cys26 and 29. There are 13 Ser/Thr phosphorylation sites plus five Tyr sites. Multiple potential splice variants are reported. There is an alternative start site 36 aa upstream of the standard site that may be accompanied by a deletion of aa 114-142. There is also a deletion of aa 88-97, and three substitutions: two aa for aa 215-262, 38 aa for aa 55-262, and 50 aa for aa 35-262. Over aa 30-113, human LAT shares 73% aa identity with mouse LAT.  

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: Flow Cytometry, ICC.

Showing Publication 1 - 1 of 1.

Publication using MAB63341	Applications	Species
JM Carpier, AE Zucchetti, L Bataille, S Dogniaux, M Shafaq-Zad, S Bardin, M Lucchino, M Maurin, LD Joannas, JG Magalhaes, L Johannes, T Galli, B Goud, C Hivroz Rab6-dependent retrograde traffic of LAT controls immune synapse formation and T cell activation J. Exp. Med., 2018-02-12;0(0):. 2018-02-12 [PMID: 29440364] (Flow Cytometry, ICC, Mouse)	Flow Cytometry, ICC	Mouse

Array MAB63341

• LAT Antibodies
• LAT ELISA Kits
• LAT Lysate
• LAT Proteins