Applications | Flow, Flow |
Clone | 508921 |
Clonality | Monoclonal |
Host | Mouse |
Conjugate | Allophycocyanin |
Immunogen | Mouse myeloma cell line NS0-derived recombinant human LAMP-1/CD107a Ala28-Asn380 Accession # P11279 |
Specificity | Detects human LAMP-1/CD107a in direct ELISAs and Western blots. |
Source | N/A |
Isotype | IgG2b |
Clonality | Monoclonal |
Host | Mouse |
Gene | LAMP1 |
Purity Statement | Protein A or G purified from hybridoma culture supernatant |
Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
Storage | Protect from light. Do not freeze.
|
Buffer | Supplied in a saline solution containing BSA and Sodium Azide. |
Preservative | Sodium Azide |
Lysosome-Associated Membrane Protein-1 (LAMP-1), also known as CD107a, is a 100-130 kDa member of the LAMP family of glycoproteins. It is expressed in lysosomal and plasma membranes of macrophages, NK and T-cells, and with LAMP-2, is essential for the formation of phagolysosomes. On the cell surface, it also presents carbohydrates to selectins. Mature human LAMP-1 is a 389 amino acid (aa) type I transmembrane glycoprotein. It contains a 354 aa luminal/extracellular domain (ECD) (aa 28-381) and a 12 aa cytoplasmic tail (aa 405-416). The ECD has two large looping regions (aa 28-193 and 227-381) plus multiple N- and O-linked glycosylation sites. There is one potential splice variant that shows a 26 aa substitution in the signal sequence. Over aa 28-380, human LAMP-1 shares 64% aa identity with mouse LAMP-1.
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Gene Symbol | LAMP1 |