| Reactivity | HuSpecies Glossary |
| Applications | WB, ICC/IF |
| Clonality | Polyclonal |
| Host | Sheep |
| Conjugate | Unconjugated |
| Concentration | LYOPH |
| Immunogen | E. coli-derived recombinant human Importin alpha 2/KPNA2 Met1-Asp132 Accession # P52292 |
| Specificity | Detects human Importin alpha 2/KPNA2 in Western blots. |
| Source | N/A |
| Isotype | IgG |
| Clonality | Polyclonal |
| Host | Sheep |
| Gene | KPNA2 |
| Purity Statement | Antigen Affinity-purified |
| Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
| Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
| Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS. |
| Preservative | No Preservative |
| Concentration | LYOPH |
| Reconstitution Instructions | Reconstitute at 0.2 mg/mL in sterile PBS. |
KPNA2 (Karyopherin subunit alpha 2; also SRP1 alpha , importin subunit alpha 2 and RAG1) is a 58-60 kDa member of the importin alpha family of proteins. It is ubiquitously expressed, and found in both nucleus and cytoplasm. KPNA2 functions as a cargo carrier that transports various complexes from cytoplasm into nucleus. For the MRN DNA repair complex, KPNA2 first binds to NBS1, and then to importin beta 1, which mediates movement through the nuclear pore. Human KPNA2 is 529 amino acids (aa) in length. It contains an N-terminal IBB/importin beta domain (aa 2-60), ten Armadillo repeats that bind "cargo" (aa 71-496) and three intervening NLSs. There is one splice variant that shows a deletion of aa 72-310, coupled to an 11 aa substitution for aa 389-406. Over aa 1-132, human KPNA2 shares 94% aa identity with mouse KPNA2.
![Importin alpha 2/KPNA2 Antibody [Unconjugated]](/sites/all/modules/enterprise-tech/et_datasheets/images/novus_guarantee.png "Importin alpha 2/KPNA2 Antibody [Unconjugated]")
Secondary Antibodies |
Isotype Controls |
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