Importin-13 Antibody

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13. Expressed in fetal brain, heart, intestine and kidney. Belongs to the importin beta family. Contains 14 HEAT repeats. Contains 1 importin N-terminal domain.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 1 application: WB.

Showing Publications 1 - 5 of 5.

Publications using NBP1-31508	Applications	Species
Ye Y, Lv C, Sun J et al. XPO1-Mediated EIF1AX Cytoplasmic Relocation Promotes Tumor Migration and Invasion in Endometrial Carcinoma Oxidative medicine and cellular longevity 2022-12-22 [PMID: 36589683] (WB, Mouse)	WB	Mouse
Zhou J, Simon JM, Liao C et al. An oncogenic JMJD6-DGAT1 axis tunes the epigenetic regulation of lipid droplet formation in clear cell renal cell carcinoma Molecular cell 2022-06-15 [PMID: 35764091]
Zohud BA, Guo P, Zohud BA et al. Importin 13 promotes NSCLC progression by mediating RFPL3 nuclear translocation and hTERT expression upregulation Cell Death Dis 2020-10-20 [PMID: 33082305] (WB, Human)	WB	Human
Sakuma T, Davila JI, Malcolm JA et al. Murine leukemia virus uses NXF1 for nuclear export of spliced and unspliced viral transcripts. J. Virol. 2014-01-30 [PMID: 24478440] (WB, Human)	WB	Human
Zehorai E, Seger R. Beta-like importins mediate the nuclear translocation of MAPKs. Mol Cell Biol. 2013-11-11 [PMID: 24216760] (WB, Human)	WB	Human

Array NBP1-31508

• Importin-13 Antibodies
• Importin-13 Lysate
• Importin-13 Protein