IL-17C Antibody

IL-17C, also alternatively named IL-21, is a pro-inflammatory cytokine and member of the IL-17 family. The IL-17 family is comprised of at least six member, IL-17A, IL-17B, IL-17C, IL-17D, IL-17E and IL-17F (1, 2). IL-17C, along with IL-17B, appears to stimulate release of TNF and IL-1 from the monocytic THP-1 cell line thus appearing to have a different receptor and induction pattern than IL-17A (1, 2). As a pro-inflammatory cytokine IL-17C augments the inflammatory process in arthritis models (2, 3). IL-17C is induced in epithelial cells by bacterial antigens and other inflammatory ligands such as imiquimod, exhibiting a direct linkage with innate immune receptors such as TLRs (2, 3). The IL-17C receptor complex appears to be comprised of IL-17RA or IL-17RE. Antibody to IL-17C allows further analysis of the unique regulatory activity, cellular receptors and cellular targets of IL-17C versus other members of the IL-17 family such as IL-17A. The study of IL-17C and its contribution to diseases caused by impaired epithelial barriers in autoimmune and inflammatory diseases such as psoriasis, asthma or inflammatory bowel disease potentiate development of new therapies directed at regulation of IL-17C or other IL-17 family members (4). The linkage of IL-17C with epithelial cells also furthers the study of the innate immune functions of epithelial cells.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array NBP2-27100

• IL-17C Antibodies
• IL-17C Lysate
• IL-17C Protein
• IL-17C Proteins and Enzymes
• IL-17C ELISA