Human TIM-3 DuoSet ELISA, 15 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

TIM-3 (T cell immunoglobulin and mucin domain-3), also known as HAVCR2 is an immunosuppressive protein that enhances tolerance and inhibits anti-tumor immunity. It is upregulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). TIM-3 ligation by Galectin-9 attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. Dendritic cell-expressed TIM-3 dampens inflammation by enabling the phagocytosis of apoptotic cells and the cross-presentation of apoptotic cell antigens. TIM-3 also binds the alarmin HMGB1, thereby preventing the activation of TLRs in response to released tumor cell DNA.

We have publications tested in 2 confirmed species: Human, E. coli.

Showing Publications 1 - 5 of 5.

Publications using DY2365	Applications	Species
Grannes, H;Ueland, T;Simeone, P;Liani, R;Guagnano, MT;Aukrust, P;Michelsen, AE;Birkeland, K;di Castelnuovo, A;Cipollone, F;Consoli, A;Halvorsen, B;Gregersen, I;Santilli, F; Liraglutide and not lifestyle intervention reduces soluble CD163 after comparable weight loss in obese participants with prediabetes or type 2 diabetes mellitus Cardiovascular diabetology 2024-04-29 [PMID: 38685051] (Human)		Human
L Chavez-Gal, A Ruiz, K Martinez-E, H Aguilar-Du, M Torres, R Falfan-Val, G Pérez-Rubi, M Selman, I Buendia-Ro Circulating Levels of PD-L1, TIM-3 and MMP-7 Are Promising Biomarkers to Differentiate COVID-19 Patients That Require Invasive Mechanical Ventilation Biomolecules, 2022-03-14;12(3):. 2022-03-14 [PMID: 35327637] (Human)		Human
S Schlichtne, NH Meyer, IM Yasinska, N Aliu, SM Berger, BF Gibbs, E Fasler-Kan, VV Sumbayev Functional role of galectin-9 in directing human innate immune reactions to Gram-negative bacteria and T cell apoptosis International immunopharmacology, 2021-09-17;100(0):108155. 2021-09-17 [PMID: 34543981] (E. coli)		E. coli
Y Palacios, A Ruiz, LA Ramón-Luin, R Ocaña-Guzm, O Barreto-Ro, A Sánchez-Mo, B Tecuatzi-C, AG Regalado-G, RD Pineda-Gud, A García-Mar, F Juárez-Her, JP Farias-Con, I Fricke-Gal, G Pérez-Rubi, R Falfán-Val, I Buendia-Ro, K Medina-Que, L Chavez-Gal Severe COVID-19 Patients Show an Increase in Soluble TNFR1 and ADAM17, with a Relationship to Mortality International Journal of Molecular Sciences, 2021-08-05;22(16):. 2021-08-05 [PMID: 34445140] (Human)		Human
H Hoel, T Ueland, M Hove-Skovs, HJ Hartling, M Gelpi, T Benfield, H Ullum, AE Michelsen, P Aukrust, SD Nielsen, M Trøseid Soluble T-Cell Immunoglobulin Mucin Domain-3 Is Associated With Hepatitis C Virus Coinfection and Low-Grade Inflammation During Chronic Human Immunodeficiency Virus Infection Open Forum Infect Dis, 2020-01-29;7(2):ofaa033. 2020-01-29 [PMID: 32055642] (Human)		Human

Array DY2365

• TIM-3 Antibodies
• TIM-3 Antibody Pair
• TIM-3 Lysate
• TIM-3 Proteins
• TIM-3 Proteins and Enzymes
• TIM-3 ELISAs