Human alpha-Fetoprotein Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

alpha-Fetoprotein (AFP), is albuminoid superfamily protein that is synthesized in the fetus primarily by the liver, yolk sac, and tissues of gastrointestinal origin. It is one of the earliest markers of the hepatocyte lineage. AFP acts as a carrier protein for steroids, bilirubin, fatty acids, retinoids, and flavonoids. In addition, it can exert immunosuppressive activity, regulate cell proliferation and apoptosis, initiate intracellular signaling, and contribute to cell invasion. Altered levels of both fetal and maternal AFP have been associated with hypothyroidism, autoimmune disorders, and heart defects. Low maternal serum AFP levels are associated with a higher incidence of Down syndrome, whereas higher levels are associated with spina bifida and anencephaly. Elevated AFP levels are also coincident with liver, stomach, and germ cell cancers.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 1 application: Flow Cytometry.

Showing Publications 1 - 10 of 12. Show All 12 Publications. Collapse Publications.

Publications using DAFP00	Applications	Species
Schmithals, C;Kakoschky, B;Denk, D;von Harten, M;Klug, JH;Hintermann, E;Dropmann, A;Hamza, E;Jacomin, AC;Marquardt, JU;Zeuzem, S;Schirmacher, P;Herrmann, E;Christen, U;Vogl, TJ;Waidmann, O;Dooley, S;Finkelmeier, F;Piiper, A; Tumour-specific activation of a tumour-blood transport improves the diagnostic accuracy of blood tumour markers in mice EBioMedicine 2024-06-17 [PMID: 38889481] (Mouse)		Mouse
K Kamimura, T Yokoo, H Abe, N Sakai, T Nagoya, Y Kobayashi, M Ohtsuka, H Miura, A Sakamaki, H Kamimura, N Miyamura, H Nishina, S Terai Effect of Diphtheria Toxin-Based Gene Therapy for Hepatocellular Carcinoma Cancers (Basel), 2020-02-18;12(2):. 2020-02-18 [PMID: 32085552] (Mouse)		Mouse
W Yang, SA Gibson, Z Yan, H Wei, J Tao, B Sha, H Qin, EN Benveniste Protein kinase 2 (CK2)�controls CD4+ T cell effector function in the pathogenesis of colitis Mucosal Immunol, 2020-01-27;0(0):. 2020-01-27 [PMID: 31988467] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
T Miyoshi, H Hosoda, M Nakai, K Nishimura, M Miyazato, K Kangawa, T Ikeda, J Yoshimatsu, N Minamino Maternal biomarkers for fetal heart failure in fetuses with congenital heart defects or arrhythmias Am. J. Obstet. Gynecol., 2018-09-28;220(1):104.e1-104.e1. 2018-09-28 [PMID: 30273582] (Human)		Human
ZF Wang, R Hu, JM Pang, GZ Zhang, W Yan, ZN Li Serum long noncoding RNA LRB1 as a potential biomarker for predicting the diagnosis and prognosis of human hepatocellular carcinoma Oncol Lett, 2018-05-30;16(2):1593-1601. 2018-05-30 [PMID: 30008842] (Human)		Human
HM Hwang, CK Heo, HJ Lee, SS Kwak, WH Lim, JS Yoo, DY Yu, KJ Lim, JY Kim, EW Cho Identification of anti-SF3B1 autoantibody as a diagnostic marker in patients with hepatocellular carcinoma J Transl Med, 2018-06-28;16(1):177. 2018-06-28 [PMID: 29954402] (Human)		Human
Dudek H, Wong D, Arvan R, Shah A, Wortham K, Ying B, Diwanji R, Zhou W, Holmes B, Yang H, Cyr W, Zhou Y, Shah A, Farkiwala R, Lee M, Li Y, Rettig G, Collingwood M, Basu S, Behlke M, Brown B Knockdown of beta-catenin with dicer-substrate siRNAs reduces liver tumor burden in vivo. Mol Ther, 2013-10-03;22(1):92-101. 2013-10-03 [PMID: 24089139] (Human)		Human
Falix FA, Aronson DC, Lamers WH, Hiralall JK, Seppen J DLK1, a serum marker for hepatoblastoma in young infants. Pediatr Blood Cancer, 2011-12-16;59(0):743. 2011-12-16 [PMID: 22180200] (Human)		Human
Buhimschi CS, Bhandari V, Dulay AT, Nayeri UA, Abdel-Razeq SS, Pettker CM, Thung S, Zhao G, Han YW, Bizzarro M, Buhimschi IA Proteomics mapping of cord blood identifies haptoglobin "switch-on" pattern as biomarker of early-onset neonatal sepsis in preterm newborns. PLoS ONE, 2011-10-10;6(10):e26111. 2011-10-10 [PMID: 22028810] (Human)		Human
Kwon OJ, Kim PH, Huyn S, Wu L, Kim M, Yun CO A hypoxia- and alpha-fetoprotein-dependent oncolytic adenovirus exhibits specific killing of hepatocellular carcinomas. Clin. Cancer Res., 2010-12-15;16(24):6071-82. 2010-12-15 [PMID: 21169258] (Human)		Human
Wu FX, Wang Q, Zhang ZM, Huang S, Yuan WP, Liu JY, Ban KC, Zhao YN Identifying serological biomarkers of hepatocellular carcinoma using surface-enhanced laser desorption/ionization-time-of-flight mass spectroscopy. Cancer Lett., 2009-03-05;279(2):163-70. 2009-03-05 [PMID: 19268439] (Human)		Human
Tanaka Y, Akiyama H, Kuroda T, Jung G, Tanahashi K, Sugaya H, Utsumi J, Kawasaki H, Hirano H A novel approach and protocol for discovering extremely low-abundance proteins in serum. Proteomics, 2006-09-01;6(17):4845-55. 2006-09-01 [PMID: 16878292] (Human)		Human
Show All 12 Publications. Collapse Publications.

Array DAFP00

• alpha-Fetoprotein/AFP Antibodies
• alpha-Fetoprotein/AFP Antibody Pair
• alpha-Fetoprotein/AFP ELISA Kits
• alpha-Fetoprotein/AFP Lysate
• alpha-Fetoprotein/AFP Proteins
• alpha-Fetoprotein/AFP ELISAs