Hemoglobin beta Antibody (1G8) - Chimeric Summary
Description |
This is a chimeric antibody made using the variable domain sequences of the original Mouse IgG2a to improve compatibility with existing reagents, assays, and techniques. |
Additional Information |
Recombinant Monoclonal Antibody |
Immunogen |
The original antibody was generated by immunizing BALB/c mice with synthetic N-terminal glycopeptide (VHLTPEC) and KLH conjugate. (Uniprot# P68871) |
Specificity |
This antibody binds human hemoglobin glycated at the N-terminal valine of the hemoglobin beta chain and does not cross react with non-glycated hemoglobin. |
Isotype |
IgG |
Clonality |
Monoclonal |
Host |
Rabbit |
Gene |
HBB |
Purity |
Protein A purified |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Packaging, Storage & Formulations
Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
Buffer |
PBS |
Preservative |
0.02% Proclin 300 |
Concentration |
1 mg/ml |
Purity |
Protein A purified |
Alternate Names for Hemoglobin beta Antibody (1G8) - Chimeric
Background
The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin causes sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia. The order of the genes in the beta-globin cluster is 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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