HDAC7 [p Ser448] Antibody Summary
Immunogen |
Within the range of amino acids 443-460 of human HDAC-7 protein were used as the immunogen ('b' represents a phosphorylated serine at position 448). |
Epitope |
CLSRAQbSPAA |
Modification |
p Ser448 |
Predicted Species |
Mouse (90%). Backed by our 100% Guarantee. |
Isotype |
IgG |
Clonality |
Polyclonal |
Host |
Rabbit |
Gene |
HDAC7 |
Purity |
Immunogen affinity purified |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Dilutions |
- Western Blot 0.1-0.5 ug/ml
|
Reactivity Notes
Reacts with Chimpanzee and New World Monkey. Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (90%).
Packaging, Storage & Formulations
Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
Buffer |
0.1 ml PBS and 0.05% BSA |
Preservative |
0.05% Sodium Azide |
Purity |
Immunogen affinity purified |
Alternate Names for HDAC7 [p Ser448] Antibody
Background
Histone deacetylase 7 is a thymus-specific, intracellular transcription factor belonging to the class IIa histone deacetylase family. Reports suggest that dephosphorylation and nuclear localization of HDAC-7 is promoted by Myosin phosphatase, thus regulating the repression of Nur77 and inhibition of apoptosis in CD4+CD8+ double-positive thymocytes. HDAC-7 plays a specific role in maintaining vascular integrity by repressing the expression of matrix metalloproteinase (MMP) 10. It promotes repression mediated by transcriptional corepressor NCOR2 and is an efficient corepressor of the androgen receptor (AR). It is also responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4).
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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Publications for HDAC7 Antibody (NBP2-03979) (0)
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Product General Protocols
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Video Protocols
FAQs for HDAC7 Antibody (NBP2-03979). (Showing 1 - 1 of 1 FAQ).
-
I'm interested in NBP2-03979. I would like to know whether it can be used for mouse brain tissue by WB. Have you ever tested it with mouse sample?
- Our HDAC7 (pSer448) antibody with catalogue number NBP2-03979 has not yet been tested with mouse samples. However since the homology between the peptide immunogen and the mouse protein sequence is very high, at 90%, we do guarantee this antibody for use with mouse samples.
Secondary Antibodies
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