GABA-B R1 [p Ser923] Antibody Summary
Immunogen |
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser923 conjugated to KLH. Accession # Q9Z0U4 |
Modification |
p Ser923 |
Specificity |
Specific for endogenous levels of the ~102 kDa GABA-B R1 phosphorylated at Ser923. Immunolabeling is completely eliminated by treatment with lambda-phosphatase. |
Predicted Species |
Human (100%), Primate (100%), Bovine (100%). Backed by our 100% Guarantee. |
Isotype |
IgG |
Clonality |
Polyclonal |
Host |
Rabbit |
Gene |
GABBR1 |
Purity |
Antigen Affinity-purified |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Dilutions |
|
Theoretical MW |
102 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Packaging, Storage & Formulations
Storage |
Store at -20C. Avoid freeze-thaw cycles. |
Buffer |
10mM HEPES (pH 7.5), 0.15M NaCl, 0.1 mg/ml BSA and 50% Glycerol |
Preservative |
No Preservative |
Purity |
Antigen Affinity-purified |
Alternate Names for GABA-B R1 [p Ser923] Antibody
Background
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAB receptors are heterodimeric G protein-coupled receptors that mediate slow synaptic inhibition in the central nervous system. Phosphorylation enhances GABAB receptor effector coupling (Couve et al., 2004). Phosphorylation of Ser923 is thought to be important in the regulation of GABAB receptor function.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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