GABA-B R2 Antibody [Unconjugated] - N-Terminus

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

GABBR2 is half of a heterodimeric GPCR for GABA which mediates coupling to G proteins. B-type receptors for the neurotransmitter GABA (gamma-aminobutyric acid) inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters and the activity of ion channels and adenylyl cyclase As a homodimer, GABBR2 is retained in the endoplasmic reticulum and endoplasmic reticulum-Golgi intermediate compartment.  When GBR1/GBR2 heterodimers are present they are localized to the plasma membrane. GABBR2 is differentially expressed in the nervous system. GABBR2 and GABBR1 mRNA's are coexpressed in various brain regions such as the Purkinje cell layer of the cerebellum. In situ hybridization histochemistry using an antisensce probe to this novel receptor indicates GABBR2 is found exclusively in neurons. GABBR2 is implicated in synaptic inhibition, hippocampal long-term potentiation, slow wave sleep, muscle relaxation and nociception.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Rat.

We have publications tested in 1 application: Western Blot.

Showing Publications 1 - 3 of 3.

Publications using AF1188	Applications	Species
Ming F. Lu, Qiang Fu, Tian Y. Qiu, Jian H. Yang, Qing H. Peng, Zhen Z. Hu The CaMKII‐dependent phosphorylation of GABAB receptors in the nucleus accumbens was involved in cocaine‐induced behavioral sensitization in rats CNS Neuroscience & Therapeutics 2023-05-01 [PMID: 36756679]
Alejandro Parga Becerra, Aric F. Logsdon, William A. Banks, Christopher B. Ransom Traumatic Brain Injury Broadly Affects GABAergic Signaling in Dentate Gyrus Granule Cells eNeuro 2021-01-29 [PMID: 33514602]
Schwenk J, Perez-Garci E, Schneider A, Kollewe A, Gauthier-Kemper A, Fritzius T, Raveh A, Dinamarca M, Hanuschkin A, Bildl W, Klingauf J, Gassmann M, Schulte U, Bettler B, Fakler B Modular composition and dynamics of native GABAB receptors identified by high-resolution proteomics. Nat Neurosci, 2015-12-21;19(2):233-42. 2015-12-21 [PMID: 26691831] (Western Blot, Rat)	Western Blot	Rat

Array AF1188

• GABA-B R2 Antibodies
• GABA-B R2 Lysate
• GABA-B R2 Proteins