GABA-B R2 Products

Description

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors the GABAA and the GABAB subtype of receptors. GABAB receptors are heterodimeric G protein-coupled receptors that mediate slow synaptic inhibition in the central nervous system. Moss and colleagues (Couve, et al., 2002) recently demonstrated that the functional coupling of GABAB R1/GABAB R2 receptors to inwardly rectifying K+ channels rapidly desensitizes. This effect is alleviated after direct phosphorylation of a single serine residue (Ser892) in the cytoplasmic tail of GABAB R2 by cyclic AMP (cAMP)-dependent protein kinase (PKA). In addition to it postsynaptic effects GABAB receptors localized to the presynaptic region have been reported to restrict the availability of synaptic vesicles for release (Sakaba and Neher, 2003).

Bioinformatics

Entrez	14401 Mouse 25451 Rat 9568 Human
Uniprot	AAH35071.2 Human NM_005458 Human O75899 Human O88871 Rat
Product By Gene ID	9568
Alternate Names	G protein-coupled receptor 51 GABA-BR2 GABA-B-R2 GABABR2GABA-B receptor 2 gamma-aminobutyric acid (GABA) B receptor, 2 gamma-aminobutyric acid type B receptor subunit 2 gb2 Gb2 GPR51GABA-B receptor, R2 subunit GPRC3BFLJ36928 G-protein coupled receptor 51 HG20HRIHFB2099

Research Areas for GABA-B R2

Find related products by research area and learn more about each of the different research areas below.

GPCR
Neuronal Cell Markers
Neuroscience
Neurotransmission
Phospho-Specific