GABA-B R2 Antibody (S81-2)

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors the GABAA and the GABAB subtype of receptors. GABAB receptors are heterodimeric G protein-coupled receptors that mediate slow synaptic inhibition in the central nervous system. Moss and colleagues (Couve, et al., 2002) recently demonstrated that the functional coupling of GABAB R1/GABAB R2 receptors to inwardly rectifying K+ channels rapidly desensitizes. This effect is alleviated after direct phosphorylation of a single serine residue (Ser892) in the cytoplasmic tail of GABAB R2 by cyclic AMP (cAMP)-dependent protein kinase (PKA). In addition to it postsynaptic effects GABAB receptors localized to the presynaptic region have been reported to restrict the availability of synaptic vesicles for release (Sakaba and Neher, 2003).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: FLOW.

Showing Publication 1 - 1 of 1.

Publication using NBP2-59335	Applications	Species
Osse AML, Pandey RS, Wirt RA et al. Reduction in GABAB on glia induce Alzheimer's disease related changes Brain, behavior, and immunity 2023-03-09 [PMID: 36906075] (FLOW, Mouse)	FLOW	Mouse

Array NBP2-59335

• GABA-B R2 Antibodies
• GABA-B R2 Lysate
• GABA-B R2 Proteins