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Endoglin/CD105 Antibody (209701) [Janelia Fluor® 646]

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications WB, Flow, IHC, CyTOF-ready, ICC/IF
Clone
209701
Clonality
Monoclonal
Host
Rat
Conjugate
Janelia Fluor 646

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
FAB1320U-100UG
Alexa Fluor 405
FAB1320V-100UG
Alexa Fluor 488
FAB1320G-100UG
Alexa Fluor 532
FAB1320X
Alexa Fluor 594
FAB1320T-100UG
Alexa Fluor 647
FAB1320R-100UG
Alexa Fluor 700
FAB1320N-100UG
Alexa Fluor 750
FAB1320S-100UG
Allophycocyanin/Cy7
FAB1320APCCY7
Biotin
FAB1320B
CoraFluor 1
FAB1320CL1
DyLight 350
FAB1320D
DyLight 405
FAB1320E
DyLight 488
FAB1320K
DyLight 550
FAB1320L
DyLight 594
FAB1320M
DyLight 650
FAB1320W
DyLight 680
FAB1320Y
DyLight 755
FAB1320Z
Fluorescein
FAB1320F-100
Fluorescein
FAB1320F-025
HRP
FAB1320H
Janelia Fluor 525
FAB1320JF525
Janelia Fluor 549
FAB1320I
Janelia Fluor 585
FAB1320JF585
Janelia Fluor 635
FAB1320JF635
Janelia Fluor 669
FAB1320JF669
PE/Atto594
FAB1320PEATT594
PE/Cy5.5
FAB1320PECY55
PE/Cy7
FAB1320PECY7
PerCP
FAB1320C
Unconjugated
MAB1320
mFluor Violet 450 SE
FAB1320MFV450
mFluor Violet 500 SE
FAB1320MFV500
mFluor Violet 610 SE
FAB1320MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB1320
Carrier Free
MAB1320
Carrier Free
MAB1320-SP
Carrier Free
FAB1320F-100
Carrier Free
FAB1320F-025
Carrier Free
FAB1320V-100UG
Carrier Free
FAB1320U-100UG
Carrier Free
FAB1320T-100UG
Carrier Free
FAB1320S-100UG
Carrier Free
FAB1320R-100UG
Carrier Free
FAB1320N-100UG
Carrier Free
FAB1320G-100UG
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Endoglin/CD105 Antibody (209701) [Janelia Fluor® 646] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse Endoglin
Glu21-Gly581 (predicted)
Accession # NP_031958
Specificity
Detects mouse Endoglin in direct ELISAs and Western blots. In Western blots, this antibody shows 100% cross-reactivity with recombinant human Endoglin.
Isotype
IgG2a
Clonality
Monoclonal
Host
Rat
Gene
ENG
Purity
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry
  • Immunocytochemistry
  • Immunohistochemistry
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified from hybridoma culture supernatant

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for Endoglin/CD105 Antibody (209701) [Janelia Fluor® 646]

  • CD105 antigen
  • CD105
  • Endoglin
  • ENDOsler-Rendu-Weber syndrome 1
  • ENG
  • HHT1FLJ41744
  • ORW
  • ORW1

Background

CD105 is a 90 kD homodimeric type I integral membrane glycoprotein, also known as endoglin. It is expressed on endothelial cells (especially on angiogenic endothelial cells) and up-regulated by hypoxia, activated monocytes, macrophages, bone marrow stromal cells, and some cytotrophoblasts. CD105 is a receptor for TGF- szlig1, TGF- szlig3 and modulates TGF- szlig signaling by interacting with TGF- szlig receptors I and/or II. CD105 also binds other growth factors such as actvin A, BMP-2 and -7. CD105 has been show to be a useful marker for identifying proliferating endothelium involved in tumor angiogenesis and can be used for tumor imaging, prognosis, as well as has therapeutic potential for some solid tumors and other angiogenic diseases.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Endoglin/CD105
Antibody (209701) [Ja ...
FAB1320J
Endoglin/CD105 Antibody (209701) [Janelia Fluor® 646]
Species: Mu
Applications: WB, Flow, IHC, CyTOF-ready, ICC/IF

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FAQs for Endoglin/CD105 Antibody (FAB1320J). (Showing 1 - 2 of 2 FAQ).

  1. I wonder if you have a CD105 or CD34 antibody suitable for IHC that is specific for human and do not bind mouse?
    • We do not have any anti-human CD34 or CD105 antibodies that are confirmed to NOT detect the mouse protein. When we have tested an antibody and confirmed that it will not react with mouse samples, we will add Mu(-) to the datasheet, and unfortunately all of our CD105 and CD34 antibodies will either detect the mouse protein, or they have not been used in mouse samples before.
  2. We are interested in CD105 antibodies that could react with dog, please let me know which products in your catalog you would recommend.
    • We do not currently carry any CD105 antibodies that have been validated for use in dog samples. However, if you are interested in testing any of our CD105 antibodies with dog samples you would be eligible for our Innovators Reward Program, in which you can get a discount voucher for the purchase price of the product. Please contact us at innovators@novusbio.com with any questions regarding this program.

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Bioinformatics

Gene Symbol ENG