CD90/Thy1 Antibody

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CD90 (also Thy1/Thymus cell antigen 1) is a 25-35 kDa glycoprotein member of the Immunoglobulin superfamily of molecules. It is expressed on neurons, ovarian follicular cells, endothelial cells, fibroblasts and circulating CD34⁺ stem cells, and appears to act as an adhesion molecule. CD90 is known to bind to integrins beta 2, beta 5 and beta 3, the latter often accompanied by additional binding to syndecan-4. In the postnatal nervous system, this inhibits neurite outgrowth while stabilizing newly formed axonal networks. In the vascular system, CD90 mediates the extravasation of leukocytes. And in lung, a CD90: alpha v beta 5 interaction inhibits the extracellular activation of latent TGF-beta . Mature human CD90 is a 111 amino acid (aa) GPI-linked protein (aa 20-130). It contains one V-type Ig-like domain (aa 20-126) with a heparin-binding motif (aa 56-60), and a GPI-anchor amidated cysteine at position 130. The integrin binding site consists of an Arg35LeuAsp37 tripeptide. CD90 apparently forms 50‑60 kDa homodimers and 150 kDa homomultimers. There is one potential isoform variant that contains a 12 aa substitution for aa 1-13. Over aa 20-141, human CD90 shares 64% aa identity with mouse CD90 and 84% or 83% with horse and dog respectively.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Canine, Porcine.

We have publications tested in 5 applications: Flow Cytomery, Flow Cytometry, ICC, IHC, IHC-Fr.

Showing Publications 1 - 10 of 13. Show All 13 Publications. Collapse Publications.

Publications using AF2067	Applications	Species
Park, S;Kim, S;Lim, K;Shin, Y;Song, K;Kang, GH;Kim, DY;Shin, HC;Cho, SG; Thermostable Basic Fibroblast Growth Factor Enhances the Production and Activity of Human Wharton's Jelly Mesenchymal Stem Cell-Derived Extracellular Vesicles International journal of molecular sciences 2023-11-17 [PMID: 38003648] (Flow Cytomery, Human)	Flow Cytomery	Human
Bin Lee, S;Abdal Dayem, A;Kmiecik, S;Min Lim, K;Sik Seo, D;Kim, HT;Kumar Biswas, P;Do, M;Kim, DH;Cho, SG; wwEfficient improvement of the proliferation, differentiation, and anti-arthritic capacity of mesenchymal stem cells by simply culturing on the immobilized FGF2 derived peptide, 44-ERGVVSIKGV-53 Journal of advanced research 2023-09-28 [PMID: 37777063] (Flow Cytometry, Human)	Flow Cytometry	Human
S Kim, Y Shin, Y Choi, KM Lim, Y Jeong, AA Dayem, Y Lee, J An, K Song, SB Jang, SG Cho Improved Wound Healing and Skin Regeneration Ability of 3,2'-Dihydroxyflavone-Treated Mesenchymal Stem Cell-Derived Extracellular Vesicles International Journal of Molecular Sciences, 2023-04-09;24(8):. 2023-04-09 [PMID: 37108128] (Flow Cytometry, Human)	Flow Cytometry	Human
Susanne N. Wijesinghe, Amel Badoume, Dominika E. Nanus, Archana Sharma‐Oates, Hussein Farah, Michelangelo Certo et al. Obesity defined molecular endotypes in the synovium of patients with osteoarthritis provides a rationale for therapeutic targeting of fibroblast subsets Clinical and Translational Medicine 4/3/2023 [PMID: 37006170]
Vrathasha V, Nikonov S, Bell B et al. Transplanted human induced pluripotent stem cells- derived retinal ganglion cells embed within mouse retinas and are electrophysiologically functional iScience 10/1/2022 [PMID: 36388952]
Andrew Bond, Vito Bruno, Jason Johnson, Sarah George, Raimondo Ascione Development and Preliminary Testing of Porcine Blood-Derived Endothelial-like Cells for Vascular Tissue Engineering Applications: Protocol Optimisation and Seeding of Decellularised Human Saphenous Veins International Journal of Molecular Sciences 6/14/2022 [PMID: 35743073]
Gudiseva HV, Vrathasha V, He J Et al. Single Cell Sequencing of Induced Pluripotent Stem Cell Derived Retinal Ganglion Cells (iPSC-RGC) Reveals Distinct Molecular Signatures and RGC Subtypes Genes (Basel) 12/24/2021 [PMID: 34946963] Details: Citation using the Azide and BSA Free version of this antibody.
Kyung Min Lim, Ahmed Abdal Dayem, Yujin Choi, Yoonjoo Lee, Jongyub An, Minchan Gil et al. High Therapeutic and Esthetic Properties of Extracellular Vesicles Produced from the Stem Cells and Their Spheroids Cultured from Ocular Surgery-Derived Waste Orbicularis Oculi Muscle Tissues Antioxidants (Basel) 8/16/2021 [PMID: 34439540]
S Kurokawa, Y Hashimoto, S Funamoto, K Murata, A Yamashita, K Yamazaki, T Ikeda, K Minatoya, A Kishida, H Masumoto In vivo recellularization of xenogeneic vascular grafts decellularized with high hydrostatic pressure method in a porcine carotid arterial interpose model PLoS ONE, 2021-07-22;16(7):e0254160. 2021-07-22 [PMID: 34292963] (IHC, Porcine)	IHC	Porcine
K Wei, I Korsunsky, JL Marshall, A Gao, GFM Watts, T Major, AP Croft, J Watts, PE Blazar, JK Lange, TS Thornhill, A Filer, K Raza, LT Donlin, CW Siebel, CD Buckley, S Raychaudhu, MB Brenner Notch signalling drives synovial fibroblast identity and arthritis pathology Nature, 2020-04-22;582(7811):259-264. 2020-04-22 [PMID: 32499639] (IHC, Human)	IHC	Human
P Kazimiercz, A Benko, M Nocun, A Przekora Novel chitosan/agarose/hydroxyapatite nanocomposite scaffold for bone tissue engineering applications: comprehensive evaluation of biocompatibility and osteoinductivity with the use of osteoblasts and mesenchymal stem cells Int J Nanomedicine, 2019-08-19;14(0):6615-6630. 2019-08-19 [PMID: 31695360] (ICC, Canine)	ICC	Canine
LSC Ward, L Sheriff, JL Marshall, JE Manning, A Brill, GB Nash, HM McGettrick Podoplanin regulates the migration of mesenchymal stromal cells and their interaction with platelets J. Cell. Sci., 2019-02-25;0(0):. 2019-02-25 [PMID: 30745334] (IHC-Fr, Human)	IHC-Fr	Human
A Sielicka, EL Sarin, W Shi, F Sulejmani, D Corporan, K Kalra, VH Thourani, W Sun, RA Guyton, M Padala Pathological Remodeling of Mitral Valve Leaflets from Unphysiologic Leaflet Mechanics after Undersized Mitral Annuloplasty to Repair Ischemic Mitral Regurgitation J Am Heart Assoc, 2018-11-06;7(21):e009777. 2018-11-06 [PMID: 30571381] (IHC, Porcine)	IHC	Porcine
Show All 13 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	ICC	Human	01/07/2016	View Summary Application Immunocytochemistry Sample Tested HMSC cells Species Human

Array AF2067

• CD90/Thy1 Antibodies
• CD90/Thy1 Proteins
• CD90/Thy1 Proteins and Enzymes