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EMMPRIN/CD147 Antibody (MEM-M6/1) [FITC]

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Product Details

Summary
Reactivity Hu, EqSpecies Glossary
Applications WB, ELISA, Flow, IHC, IP, CyTOF-ready
Clone
MEM-M6/1
Clonality
Monoclonal
Host
Mouse
Conjugate
FITC

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NB500-430AF350
Alexa Fluor 405
NB500-430AF405
Alexa Fluor 488
NB500-430AF488
Alexa Fluor 532
NB500-430AF532
Alexa Fluor 594
NB500-430AF594
Alexa Fluor 647
NB500-430AF647
Alexa Fluor 700
NB500-430AF700
Alexa Fluor 750
NB500-430AF750
Allophycocyanin
NB500-430APC
Biotin
NB500-430B
CoraFluor 1
NB500-430CL1
DyLight 350
NB500-430UV
DyLight 405
NB500-430V
DyLight 488
NB500-430G
DyLight 550
NB500-430R
DyLight 594
NB500-430DL594
DyLight 650
NB500-430C
DyLight 680
NB500-430FR
DyLight 755
NB500-430IR
HRP
NB500-430H
Janelia Fluor 525
NB500-430JF525
Janelia Fluor 549
NB500-430JF549
Janelia Fluor 585
NB500-430JF585
Janelia Fluor 635
NB500-430JF635
Janelia Fluor 646
NB500-430JF646
Janelia Fluor 669
NB500-430JF669
PE
NB500-430PE
PerCP
NB500-430PCP
Unconjugated
NB500-430
mFluor Violet 450 SE
NB500-430MFV450
mFluor Violet 500 SE
NB500-430MFV500
mFluor Violet 610 SE
NB500-430MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NB500-430
BSA Free
NB500-430
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EMMPRIN/CD147 Antibody (MEM-M6/1) [FITC] Summary

Immunogen
Protein A-CR purified soluble recombinant form of CD147, CD147Rg, which consists of the cDNA coding for the hinge region, C2-and C3 domain of human IgG1, CD147Rg is secreted by transfectants as a dimer (NM_001728.2).
Specificity
The antibody MEM-M6/1 recognizes an epitope in the N-terminal Ig domain (D1) of CD147 (Neurothelin), a 50-60 kDa type I transmembrane glycoprotein primarily expressed on all leukocytes, red blood cells, platelets and endothelial cells; it is not expressed by resting lymphocytes. The antibody MEM-M6/1 is a high-affinity antibody capable of binding to unstimulated peripheral blood T cells.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
BSG
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • CyTOF-ready
  • ELISA
  • Flow Cytometry
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Immunoprecipitation
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Equine reactivity reported in scientific literature (PMID: 24998980).

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein A purified

Alternate Names for EMMPRIN/CD147 Antibody (MEM-M6/1) [FITC]

  • 5F7
  • basigin (Ok blood group)
  • Basigin
  • BSG
  • CD147 antigen
  • CD147
  • Collagenase stimulatory factor
  • EMMPRIN
  • EMMPRINTCSF
  • Extracellular matrix metalloproteinase inducer
  • Leukocyte activation antigen M6
  • M6
  • OK blood group antigen
  • OK
  • Tumor cell-derived collagenase stimulatory factor

Background

CD147 plays a pivotal role in spermatogenesis, embryo implantation, neural network formation and tumor progression. It stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). CD147 may target monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. CD147 also seems to be a receptor for oligomannosidic glycans. In vitro, it promotes outgrowth of astrocytic processes. CD147 forms homooligomers in a cis-dependent manner on the plasma membrane. It forms a complex with MMP1 at the tumor cell surface. CD147 interacts with SLC16A1 and SLC1A3; probably a BSG dimer is associated with a monocarboxylate transporter dimer. CD147 also interacts with ATP1B2, MAG and L1CAM.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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EMMPRIN/CD147
Antibody (MEM-M6/1) [ ...
NB500-430F
EMMPRIN/CD147 Antibody (MEM-M6/1) [FITC]
Species: Hu, Eq
Applications: WB, ELISA, Flow, IHC, IP, CyTOF-ready

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol BSG
Entrez