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EGLN2/PHD1 Antibody [Biotin]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
Biotin

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EGLN2/PHD1 Antibody [Biotin] Summary

Immunogen
Partial synthetic peptide made to an N-terminal portion of the human EGLN2 / PHD1 protein (between amino acids 10-75) [UniProt Q96KS0]
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
EGLN2
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for EGLN2/PHD1 Antibody [Biotin]

  • DKFZp434E026
  • EC 1.14.11
  • EC 1.14.11.-
  • egl nine homolog 2 (C. elegans)
  • egl nine homolog 2
  • EGLN2
  • EIT6
  • Estrogen-induced tag 6
  • FLJ95603
  • HIFPH1 EGL nine (C.elegans) homolog 2
  • HIFPH1
  • HIF-PH1
  • HIF-prolyl hydroxylase 1
  • HPH-1
  • HPH-3
  • Hypoxia-inducible factor prolyl hydroxylase 1
  • PHD1
  • Prolyl hydroxylase domain-containing protein 1

Background

HIF prolyl hydroxylase 1 (HPH-3 or EGLN2) is a prolyl hydroxylase that modifies HIF-alpha. Classic prolyl hydroxylases are found in the endoplasmic reticulum and modify collagen, whereas HIF is an intracellular protein and the HPH sites do not resemble those modifying collagen. HIF is a transcriptional complex that plays a critical role in oxygen homeostasis. HPH is an essential component of the pathway through which cells sense oxygen. In the presence of oxygen, HPHs convert specific prolyl residues in HIF-alpha to hydroxyproline, leading to HIF-alpha destruction. Low oxygen levels, sensed at the cellular level, cause the HIF conversion to be reduced so that HIF is stable and there is increased angiogenesis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol EGLN2