Species: Hu
Applications: WB, IP
Host: Sheep Polyclonal
Species: Hu
Applications: WB, ICC/IF
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB, ELISA, IP
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: AC
Description
HIF prolyl hydroxylase 1 (HPH-3 or EGLN2) is a prolyl hydroxylase that modifies HIF-alpha. Classic prolyl hydroxylases are found in the endoplasmic reticulum and modify collagen, whereas HIF is an intracellular protein and the HPH sites do not resemble those modifying collagen. HIF is a transcriptional complex that plays a critical role in oxygen homeostasis. HPH is an essential component of the pathway through which cells sense oxygen. In the presence of oxygen, HPHs convert specific prolyl residues in HIF-alpha to hydroxyproline, leading to HIF-alpha destruction. Low oxygen levels, sensed at the cellular level, cause the HIF conversion to be reduced so that HIF is stable and there is increased angiogenesis.
Bioinformatics
| Uniprot |
Human
Human
Human
Human
Human
|
| Product By Gene ID |
112398 |
| Alternate Names |
- DKFZp434E026
- EC 1.14.11
- EC 1.14.11.-
- egl nine homolog 2 (C. elegans)
- egl nine homolog 2
- EIT6
- Estrogen-induced tag 6
- FLJ95603
- HIFPH1 EGL nine (C.elegans) homolog 2
- HIF-PH1
- HIF-prolyl hydroxylase 1
- HPH-1
- HPH-3
- Hypoxia-inducible factor prolyl hydroxylase 1
- PHD1
- Prolyl hydroxylase domain-containing protein 1
|
Research Areas for EGLN2/PHD1
Find related products by research area and learn more about each of the different research areas below.
CancerHypoxiaSignal Transduction
