EGFR Antibody [Biotin]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

The epidermal growth factor receptor (EGFR) subfamily of receptor tyrosine kinases comprises four members: EGFR (also known as HER1, ErbB1 or ErbB), ErbB2 (Neu, HER2), ErbB3 (HER3), and ErbB4 (HER4). All family members are type I transmembrane glycoproteins that have an extracellular domain which contains two cysteine-rich domains separated by a spacer region that is involved in ligand binding, and a cytoplasmic domain which has a membrane-proximal tyrosine kinase domain and a C-terminal tail with multiple tyrosine autophosphorylation sites. The human EGFR gene encodes a 1210 amino acid (aa) residue precursor with a 24 aa putative signal peptide, a 621 aa extracellular domain, a 23 aa transmembrane domain, and a 542 aa cytoplasmic domain. EGFR has been shown to bind a subset of the EGF family ligands, including EGF, amphiregulin, TGF-alpha , betacellulin, epiregulin, heparin-binding EGF and neuregulin-2 alpha  in the absence of a co-receptor. Ligand binding induces EGFR homodimerization as well as heterodimerization with ErbB2, resulting in kinase activation, tyrosine phosphorylation and cell signaling. EGFR can also be recruited to form heterodimers with the ligand-activated ErbB3 or ErbB4. EGFR signaling has been shown to regulate multiple biological functions including cell proliferation, differentiation, motility and apoptosis. In addition, EGFR signaling has also been shown to play a role in carcinogenesis (1-3).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 4 applications: ELISA Detection, ELISA Microarray Development, Functional Assay, Western Blot.

Showing Publications 1 - 8 of 8.

Publications using BAF231	Applications	Species
Calzadilla, L;Hernández, E;Dustet, J;Fernandez-de-Cossio-Diaz, J;León, K;Pietzke, M;Vazquez, A;Mulet, R;Boggiano, T; HEK293 producing the extracellular domain HER1: Full datasets of continuous fermentation process and metabolites analysis Data in brief 2023-10-01 [PMID: 37808545] (ELISA Detection, Human)	ELISA Detection	Human
Luca Gerosa, Christopher Chidley, Fabian Fröhlich, Gabriela Sanchez, Sang Kyun Lim, Jeremy Muhlich et al. Receptor-Driven ERK Pulses Reconfigure MAPK Signaling and Enable Persistence of Drug-Adapted BRAF-Mutant Melanoma Cells Cell Systems 11/1/2020 [PMID: 33113355]
Allison M. Claas, Lyla Atta, Simon Gordonov, Aaron S. Meyer, Douglas A. Lauffenburger Systems Modeling Identifies Divergent Receptor Tyrosine Kinase Reprogramming to MAPK Pathway Inhibition Cellular and Molecular Bioengineering 12/1/2018 [PMID: 30524510]
H Lee, M Choi, J Lim, M Jo, JY Han, TM Kim, Y Cho Magnetic Nanowire Networks for Dual-Isolation and Detection of Tumor-Associated Circulating Biomarkers Theranostics, 2018-01-01;8(2):505-517. 2018-01-01 [PMID: 29290823] (Functional Assay)	Functional Assay
Sakanyan V, Hulin P, Alves de Sousa R, Silva V, Hambardzumyan A, Nedellec S, Tomasoni C, Loge C, Pineau C, Roussakis C, Fleury F, Artaud I Activation of EGFR by small compounds through coupling the generation of hydrogen peroxide to stable dimerization of Cu/Zn SOD1. Sci Rep, 2016-02-17;6(0):21088. 2016-02-17 [PMID: 26883293] (Western Blot, Human)	Western Blot	Human
Thompson C, Bloom L, Ogiue-Ikeda M, Machida K SH2-PLA: a sensitive in-solution approach for quantification of modular domain binding by proximity ligation and real-time PCR. BMC Biotechnol, 2015-06-26;15(0):60. 2015-06-26 [PMID: 26112401] (Functional Assay, Human)	Functional Assay	Human
Bryan R, Regan H, Pirrie S, Devall A, Cheng K, Zeegers M, James N, Knowles M, Ward D Protein shedding in urothelial bladder cancer: prognostic implications of soluble urinary EGFR and EpCAM. Br J Cancer, 2015-03-17;112(6):1052-8. 2015-03-17 [PMID: 25719831] (Western Blot, Human)	Western Blot	Human
Gonzalez RM, Seurynck-Servoss SL, Crowley SA Development and validation of sandwich ELISA microarrays with minimal assay interference. J. Proteome Res., 2008-04-19;7(6):2406-14. 2008-04-19 [PMID: 18422355] (ELISA Microarray Development, Human)	ELISA Microarray Development	Human

Array BAF231

• EGFR Antibodies
• EGFR Antibody Pair
• EGFR Lysate
• EGFR Proteins
• EGFR Proteins and Enzymes
• EGFR ELISAs