Recombinant Human Desert Hedgehog C23II Protein

Desert hedgehog protein (DHH), also named HHG-3, is belonging to the hedgehog (Hh) family that are highly conserved proteins which are widely represented throughout the animal kingdom. This protein is predicted to be made as a precursor that is autocatalytically cleaved and the biologically active form of Hh molecules corresponds to approximately the N-terminal one half of the precursor molecule. The N-terminal portion is soluble and contains the signaling activity while the C-terminal portion is involved in processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the organism. DHH is essential for a variety of patterning events during development as intercellular signal. It may function as a spermatocyte survival factor in the testes and play an important role in testes development. Mature human DHH shares 97 % amino acid sequence identity with murine DHH.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Array NBP2-34949

• Desert Hedgehog C23II Proteins