Cultured A431 cells from a human epidermoid carcinoma of the vulva.
Localization
Cytoplasmic
Specificity
This is specific to a 54 kD protein. Cytokeratin 13 belongs to the type A (acidic) subfamily of low molecular weight cytokeratins and exists in combination with cytokeratin 4. Cytokeratin 13 is expressed in major components of squamous, non-keratinized epithelium, transitional epithelium, and myoepithelium. This antibody is useful for identifying carcinomas of trachea, sweat glands, bladder, extocervix, tongue, esophagus, anal canal, and the basal layer of keratinized epidermis.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
KRT13
Purity
Ascites
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Alternate Names for Cytokeratin 13 Antibody (KS-1A3)
CK13
CK-13
cytokeratin 13
Cytokeratin-13
K13cytokeratin-13
keratin 13
keratin, type I cytoskeletal 13
keratin-13
MGC161462
MGC3781
Background
Cytokeratin 13 is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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