CrkRS Antibody

CrkRS (Cdc2-related kinase, arginine/serine-rich) is a Cdc-2 related kinase that contains an arginine- and serine-rich (SR) domain and has recently been reported to interact with cyclin L1 and L2. Since it has been discovered that CrkRs pairs with a cyclin partner, it has also been given the name CDK12. CrkRs localizes to nuclear speckles and immunoprecipitates with RNA polymerse II and the SF2/ASF splicing factor and is proposed to play a role in the regulation of alternative splicing. Alternate names for CrkRS include cell division cycle 2-related protein kinase 7, CDC2-related protein kinase 7, CRKRS, CRK7, and KIAA0904.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: WB, Western Blot.

Showing Publications 1 - 6 of 6.

Publications using NB100-87011	Applications	Species
Guiro J, Fagbemi M, Tellier M et al. CAPTURE of the Human U2 snRNA Genes Expands the Repertoire of Associated Factors Biomolecules 2022-05-14 [PMID: 35625631] (Western Blot)	Western Blot
Chai Q, Li S, Collins MK et al. HIV-1 Nef interacts with the cyclin K/CDK13 complex to antagonize SERINC5 for optimal viral infectivity Cell Reports 2021-08-10 [PMID: 34380030]
Quereda V, Bayle S, Vena F et al. Therapeutic Targeting of CDK12/CDK13 in Triple-Negative Breast Cancer Cancer Cell 2019-10-08 [PMID: 31668947]
Eifler Tt, Shao W, Bartholomeeusen K et al. CDK12 increases 3' end processing of growth factor-induced c-FOS transcripts. Mol. Cell. Biol. 2014-11-10 [PMID: 25384976]
Davidson L, Muniz L, West S. 3' end formation of pre-mRNA and phosphorylation of Ser2 on the RNA polymerase II CTD are reciprocally coupled in human cells. Genes Dev. 2014-02-17 [PMID: 24478330] (WB, Human)	WB	Human
Friedrich MS Understanding and Exploiting MYCN Addiction in High-Risk Neuroblastoma Using the Example of CDK13 Thesis 2021-01-01 (WB, Human)	WB	Human

Array NB100-87011

• CrkRS Antibodies
• CrkRS Proteins