COMMD1 Antibody (762203) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

COMMD1, also known as MURR1 and the copper toxicosis gene product, is a ubiquitously expressed 21 kDa copper binding protein. It contains an N-terminal domain (aa 1-121) and C-terminal domain (aa 125-190) which are separated by a protease sensitive site. It forms high molecular weight oligomeric complexes both in solution and in association with phospholipid membranes. COMMD1 is found in the nucleus and cytoplasm as well as in endocytic vesicle membrane fractions. It binds and regulates the activity of a variety of proteins including the copper transporter Wilson disease protein (ATP7B), the delta ENaC epithelial cell sodium channel, the cystic fibrosis transmembrane regulator (CFTR), superoxide dismutase 1 (SOD1), XIAP, HIF-1 alpha, and Cullin RING ubiquitin ligases. COMMD1 promotes the ubiquitination and degradation of the RelA subunit of NFkB, thereby inhibiting its chromatin association and nuclear targeting as well as the replication of HIV in resting T cells. Within aa 37-135, human COMMD1 shares 94% aa sequence identity with mouse and rat COMMD1.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: ICC, Immunoprecipitation.

Showing Publications 1 - 4 of 4.

Publications using MAB7526	Applications	Species
Sai Srinivas Panapakkam Giridharan, Guangming Luo, Pilar Rivero-Rios, Noah Steinfeld, Helene Tronchere, Amika Singla et al. Lipid kinases VPS34 and PIKfyve coordinate a phosphoinositide cascade to regulate retriever-mediated recycling on endosomes eLife 1/18/2022 [PMID: 35040777]
CG Campion, K Zaoui, T Verissimo, S Cossette, H Matsuda, N Solban, P Hamet, J Tremblay COMMD5/HCaRG Hooks Endosomes on Cytoskeleton and Coordinates EGFR Trafficking Cell Rep, 2018-07-17;24(3):670-684.e7. 2018-07-17 [PMID: 30021164] (ICC, Human)	ICC	Human
A Fedoseienk, M Wijers, JC Wolters, D Dekker, M Smit, N Huijkman, N Kloosterhu, H Klug, A Schepers, K Willems va, JH Levels, DD Billadeau, MH Hofker, J van Deurse, M Westerterp, E Burstein, JA Kuivenhove, B van de Slu COMMD Family Regulates Plasma LDL Levels and Attenuates Atherosclerosis Through Stabilizing the CCC Complex in Endosomal LDLR Trafficking Circ. Res., 2018-03-15;0(0):. 2018-03-15 [PMID: 29545368] (Immunoprecipitation, Human, Mouse)	Immunoprecipitation	Human, Mouse
Bartuzi P, Billadeau D, Favier R, Rong S, Dekker D, Fedoseienko A, Fieten H, Wijers M, Levels J, Huijkman N, Kloosterhuis N, van der Molen H, Brufau G, Groen A, Elliott A, Kuivenhoven J, Plecko B, Grangl G, McGaughran J, Horton J, Burstein E, Hofker M, van de Sluis B CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL. Nat Commun, 2016-03-11;7(0):10961. 3/11/2016 [PMID: 26965651]

Array MAB7526

• COMMD1 Antibodies
• COMMD1 Lysate
• COMMD1 Proteins