CIZ1 Antibody

CIZ1 (Cip1 interacting zinc-finger protein) was identified as a protein that associates with the cell-cycle inhibiting protein, p21 (Cip1/Waf1). CIZ1 is a member of the matrin 3 protein family and has been shown to bind DNA consensus sequences and co-localize with PCNA during replication. In breast cancer cells, CIZ1 was shown to associate with Cdk2 and dynein light chain 1 (DLC1), a cytoskeletal signaling protein involved in cell cycle regulation and tumorigenesis. Studies of the role of CIZ1 in breast tumorigenesis revealed that CIZ1 is an estrogen-responsive gene that functions as a coactivator of the estrogen receptor. Targeted depletion of CIZ1 inhibits entry into S-phase. This finding along with evidence that CIZ1 interacts with multiple cell cycle regulatory proteins and localizes to DNA replication foci, indicates that CIZ1 plays a critical role in the regulation of DNA replication.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: ICC/IF, WB.

Showing Publications 1 - 10 of 10.

Publications using NB100-74624	Applications	Species
Coverley D, Higgins G, West D et al. A quantitative immunoassay for lung cancer biomarker CIZ1b in patient plasma. Clin. Biochem. 2016-11-17 [PMID: 27867087] (WB)	WB
Turvey G, de Alba E, Stewart E et al. Dominant CIZ1 fragments drive epigenetic instability and are expressed in early stage cancers bioRxiv 2023-09-22 (ICC/IF, WB) Details: ICC/IF Dilution 1:1000, WB dilution 1:100	ICC/IF, WB
Iris Dror, Tsotne Chitiashvili, Shawn Y X Tan, Clara T Cano, Anna Sahakyan, Yolanda Markaki, Constantinos Chronis, Amanda J Collier, Weixian Deng, Guohao Liang, Yu Sun, Anna Afasizheva, Jarrett Miller, Wen Xiao, Douglas L Black, Fangyuan Ding, Kathrin Plath XIST directly regulates X-linked and autosomal genes in naive human pluripotent cells. Cell 2024-01-08 [PMID: 38181737]
Amy Pandya-Jones, Yolanda Markaki, Jacques Serizay, Tsotne Chitiashvili, Walter Mancia, Andrey Damianov, Costantinos Chronis, Bernadett Papp, Chun-Kan Chen, Robin McKee, Xiao-Jun Wang, Anthony Chau, Shan Sabri, Heinrich Leonhardt, Sika Zheng, Mitchell Guttman, Douglas. L. Black, Kathrin Plath A protein assembly mediates Xist localization and gene silencing Nature 2020-06-18 [PMID: 32908311]
Ridings-Figueroa R, Stewart ER, Nesterova TB et al. The nuclear matrix protein CIZ1 facilitates localization of Xist RNA to the inactive X-chromosome territory. Genes Dev. 2017-05-25 [PMID: 28546514] (ICC/IF, Mouse)	ICC/IF	Mouse
Markaki Y, Chong J, Luong C et al. Xist-seeded nucleation sites form local concentration gradients of silencing proteins to inactivate the X-chromosome bioRxiv 2020-11-23
Ogawa A, Ogawa Y A Quick Immuno-FISH Protocol for Detecting RNAs, Proteins, and Chromatin Modifications Methods in molecular biology (Clifton, N.J.) 2021-12-16 [PMID: 33326080]
Tan SYX, Dror I, Plath K Characterizing the genome-wide localization of the Xist lncRNA and its effect on gene silencing Book Jan 1 2021
Dror I, Chitiashvili T, Sahakyan A XIST controls X chromosome dampening and autosomal genes in early human development Book 2021-01-01
Markaki Y, Gan Chong J, Wang Y Et al. Xist nucleates local protein gradients to propagate silencing across the X chromosome Cell 2021-11-04 [PMID: 34813726]

Array NB100-74624

• CIZ1 Antibodies
• CIZ1 Lysates
• CIZ1 Protein