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CIP2A Antibody (2G10) [mFluor Violet 450 SE]

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CIP2A Antibody (2G10) [mFluor Violet 450 SE] [NB110-59722MFV450] - Vial of mFluor Violet 450 conjugated antibody. mFluor Violet 450 is optimally excited at 406 nm by the Violet laser (405 nm) and has an emission maximum of 445 nm.
CIP2A Antibody (2G10) [mFluor Violet 450 SE] [NB110-59722MFV450] - Vial of mFluor Violet 450 conjugated antibody. mFluor Violet 450 is optimally excited at 406 nm by the Violet laser (405 nm) and has an emission maximum ...read more

Product Details

Summary
Reactivity Hu, Mu, Rt, PmSpecies Glossary
Applications WB, Flow, ICC/IF, IHC, KD
Clone
2G10
Clonality
Monoclonal
Host
Mouse
Conjugate
mFluor Violet 450 SE

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NB110-59722AF350
Alexa Fluor 405
NB110-59722AF405
Alexa Fluor 488
NB110-59722AF488
Alexa Fluor 532
NB110-59722AF532
Alexa Fluor 594
NB110-59722AF594
Alexa Fluor 647
NB110-59722AF647
Alexa Fluor 700
NB110-59722AF700
Alexa Fluor 750
NB110-59722AF750
Allophycocyanin
NB110-59722APC
Allophycocyanin/Cy7
NB110-59722APCCY7
Biotin
NB110-59722B
CoraFluor 1
NB110-59722CL1
DyLight 350
NB110-59722UV
DyLight 405
NB110-59722V
DyLight 488
NB110-59722G
DyLight 550
NB110-59722R
DyLight 594
NB110-59722DL594
DyLight 650
NB110-59722C
DyLight 680
NB110-59722FR
DyLight 755
NB110-59722IR
FITC
NB110-59722F
HRP
NB110-59722H
Janelia Fluor 525
NB110-59722JF525
Janelia Fluor 549
NB110-59722JF549
Janelia Fluor 646
NB110-59722JF646
Janelia Fluor 669
NB110-59722JF669
PE
NB110-59722PE
PE/Atto594
NB110-59722PEATT594
PE/Cy5.5
NB110-59722PECY55
PE/Cy7
NB110-59722PECY7
Unconjugated
NB110-59722
mFluor Violet 500 SE
NB110-59722MFV500
mFluor Violet 610 SE
NB110-59722MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NB110-59722
Azide and BSA Free
NBP2-80670
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CIP2A Antibody (2G10) [mFluor Violet 450 SE] Summary

Immunogen
A synthetic peptide made to a C-terminal portion of the human CIP2A protein. [UniProt# Q8TCG1]
Isotype
IgG2b Kappa
Clonality
Monoclonal
Host
Mouse
Gene
CIP2A
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Knockdown Validated
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Other species have not been tested.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes

mFluor(TM) is a trademark of AAT Bioquest, Inc. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for CIP2A Antibody (2G10) [mFluor Violet 450 SE]

  • Cancerous inhibitor of PP2A
  • CIP2A
  • FLJ12850
  • KIAA1524
  • MGC163436
  • p90 autoantigen
  • p90
  • protein CIP2A

Background

Inhibition of protein phosphatase 2A (PP2A) activity has been identified as a prerequisite for the transformation of human cells. The protein, designated Cancerous Inhibitor of PP2A (CIP2A), interacts directly with the oncogenic transcription factor c-Myc, inhibits PP2A activity toward c-Myc serine 62 (S62), and thereby prevents c-Myc proteolytic degradation. In addition to its function in c-Myc stabilization, CIP2A promotes anchorage-independent cell growth and in vivo tumor formation. The oncogenic activity of CIP2A is demonstrated by transformation of human cells by overexpression of CIP2A. Importantly, CIP2A is overexpressed in two common human malignancies, head and neck squamous cell carcinoma (HNSCC) and colon cancer.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for CIP2A Antibody (NB110-59722MFV450) (0)

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Secondary Antibodies

 

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Blogs on CIP2A.

Check out the latest blog posts on CIP2A.
CIP2A - A lean, mean, oncoprotein machine
The CIP2A protein was originally identified as p90, a cytoplasmic auto-antigen from the serum of a cancer patient. It was later found to inhibit protein phosphatase 2A (PP2A) activity as well as interact with c-myc. CIP2A's inhibitory activity blocks ...  Read full blog post.
CIP2A: The Cancerous Inhibitor of Protein Phosphatase 2A
The autoantigen p90 is a recently discovered protein that binds to and inhibits Protein Phosphatase 2A (PP2A) activity, thereby playing a critical role in cancer progression. Thus, p90 was renamed the "cancerous inhibitory protein of PP2A" or CIP2A....  Read full blog post.
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Bioinformatics

Gene Symbol CIP2A