CD117/c-kit Antibody (2B8) - BSA Free

CD117 is a 145 kD immunoglobulin superfamily member, also known as c-Kit and stem cell factor receptor (SCFR). It is a transmembrane tyrosine-kinase receptor that binds the c-Kit ligand (also known as steel factor, stem cell factor, and mast cell growth factor). CD117 is expressed on hematopoietic stem cells (including multipotent hematopoietic stem cells, progenitors committed to myeloid and/or erythroid lineages, and T and B cell precursors), mast cells, and acute myeloid leukemia (AML) cells. CD117 interaction with it's ligand is critical for the development of hematopoietic stem cells. The 2B8 antibody does not block c-Kit activity.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: FLOW, ICC/IF, IF/IHC.

Showing Publications 1 - 10 of 11. Show All 11 Publications. Collapse Publications.

Publications using NB100-77477	Applications	Species
Winship AL, Griffiths M, Lliberos Requesens C et al. The PARP inhibitor, olaparib, depletes the ovarian reserve in mice: implications for fertility preservation Hum. Reprod. 2020-06-30 [PMID: 32604417] (ICC/IF, Mouse)	ICC/IF	Mouse
Camberos V, Baio J, Bailey L et al. Effects of Spaceflight and Simulated Microgravity on YAP1 Expression in Cardiovascular Progenitors: Implications for Cell-Based Repair Int J Mol Sci 2019-06-04 [PMID: 31167392] (FLOW, Human)	FLOW	Human
Hernandez I, Baio JM, Tsay E et al. Short-term hypoxia improves early cardiac progenitor cell function in vitro Am J Stem Cells. [PMID: 29531855] (FLOW, Human)	FLOW	Human
Baio J, Martinez AF, Bailey L, et al. Spaceflight Activates Protein Kinase C Alpha Signaling and Modifies the Developmental Stage of Human Neonatal Cardiovascular Progenitor Cells Stem Cells Dev 2018-01-12 [PMID: 29320953] (Human)		Human
Baio Jonathan M, Walden Ryan C, Fuentes Tania I et al. A Hyper-Crosslinked CarbohydRate Polymer Scaffold Facilitates Lineage Commitment and Maintains a Reserve Pool of ProlifeRating Cardiovascular Progenitors. Transplantation Direct 2017-01-01 [PMID: 28573188] (FLOW, Human) Details: This citation used the DyLight 650 version of this antibody.	FLOW	Human
Uchida H, Machida M, Miura T et al. A xenogeneic-free system generating functional human gut organoids from pluripotent stem cells JCI Insight. [PMID: 28097227] (IF/IHC, Human)	IF/IHC	Human
Meyer S, Maufort JP, Nie J et al. Development of an Efficient Targeted Cell-SELEX Procedure for DNA Aptamer Reagents PLoS One 2013-08-23 [PMID: 23967247] (FLOW, Human)	FLOW	Human
Charles N, Hardwick D, Daugas E et al. Basophils and the T helper 2 environment can promote the development of lupus nephritis. Nat Med. 2010-06-01 [PMID: 20512127] (FLOW)	FLOW
Bachelet I et al. J. Immunol. 180:6064. 2008-01-01 [PMID: 18424727]
Podd BS et al. J. Immunol. 176:6532. 2006-01-01 [PMID: 16709810]
Ikuta K, Weissman IL. Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation. P. Natl. Acad. Sci. USA 89:1502. 1992-01-01 [PMID: 1371359]
Show All 11 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	1 reviewed by: Fumihito Noguchi	IHC-P	Human	01/02/2018	View Summary Application Immunohistochemistry-Paraffin Sample Tested human skin Species Human Lot Lot# B221800 Comments Comments We tested CD117/c-kit antibody (2B8) for IHC-P (human skin) and confirmed that it did not work to detect human melanocytes which are reportedly positive for ckit, indicating that this product is not applicable for FFPE section.

Array NB100-77477

• CD117/c-kit Antibodies
• CD117/c-kit ELISA Kits
• CD117/c-kit Lysates
• CD117/c-kit Proteins
• CD117/c-kit ELISAs
• CD117/c-kit Proteins and Enzymes