Species: Hu, Mu
Applications: WB, Simple Western, Flow, IHC, CyTOF-ready, Dual ISH-IHC
Host: Goat Polyclonal
Species: Hu
Applications: WB, Simple Western, Flow, IHC, B/N, CyTOF-ready
Host: Goat Polyclonal
Species: Hu, Mu
Applications: Flow, ICC/IF, IHC, IP
Host: Rat Monoclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: ELISA
Species: Rt
Applications: ELISA
Species: Hu
Applications: WB
Species: Hu
Applications: Bioactivity
Species: Hu
Applications: Bioactivity
Species: Hu
Applications: Bioactivity
Description
CD117 is a 145 kD immunoglobulin superfamily member, also known as c-Kit and stem cell factor receptor (SCFR). It is a transmembrane tyrosine-kinase receptor that binds the c-Kit ligand (also known as steel factor, stem cell factor, and mast cell growth factor). CD117 is expressed on hematopoietic stem cells (including multipotent hematopoietic stem cells, progenitors committed to myeloid and/or erythroid lineages, and T and B cell precursors), mast cells, and acute myeloid leukemia (AML) cells. CD117 interaction with it's ligand is critical for the development of hematopoietic stem cells. The 2B8 antibody does not block c-Kit activity.
Bioinformatics
| Entrez |
Mouse
Human
Rat
|
| Uniprot |
Human
Human
Human
Human
Human
Mouse
Human
Human
|
| Product By Gene ID |
3815 |
| Alternate Names |
- CD117 antigen
- CD117
- ckit
- C-Kit
- EC 2.7.10
- EC 2.7.10.1
- PBT
- piebald trait
- Proto-oncogene c-Kit
- proto-oncogene tyrosine-protein kinase Kit
- SCFRmast/stem cell growth factor receptor
- soluble KIT variant 1
- Tyrosine-protein kinase Kit
- v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
- v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein
|
Related CD117/c-kit Blog Posts
Check out the latest blog posts on CD117/c-kit.
Do you see what I see? I c-Kit
The c-Kit (CD117) proto-oncogene is a 145 kD receptor tyrosine kinase family closely related to platelet-derived growth factor receptor (PDGFR). It is a transmembrane receptor and the cellular homolog of the HZ4-feline sarcoma virus transforming gene ... Read more.
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Read more CD117/c-kit related blogs.
![Immunohistochemistry CD117/c-kit Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/SCF_R_AF1356_Immunohistochemistry_9746.jpg)
![Neutralization CD117/c-kit Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/SCF_R_AF332_Block_Neutralize_8849.jpg)
![N/A CD117/c-kit [Biotin]](http://images.novusbio.com/fullsize2/DATA_CD117_DY332_ELISA_1933.jpg)
![Bioactivity CD117/c-kit [Unconjugated]](http://images.novusbio.com/fullsize2/10961-sr_recombinant-human-cd117-c-kit-fc-chimera-protein-cf-bioactivity-172202283733.jpg)
![Binding Activity CD117/c-kit [Biotin]](http://images.novusbio.com/fullsize2/avi10703_recombinant-human-cd117-c-kit-fc-chimera-avi-tag-protein-cf-binding-activity-1522021201553.jpg)
![Western Blot CD117/c-kit Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/CD117_AF1356_Western_Blot_18637.jpg)
![Simple Western CD117/c-kit Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/CD117_AF1356_Simple_Western_17480.jpg)
![Immunocytochemistry/ Immunofluorescence CD117/c-kit Antibody [Unconjugated]](http://images.novusbio.com/fullsize/af1356_human-mouse-cd117-c-kit-affinity-purified-polyclonal-ab-4120241033412.jpg)
![In-situ Hybridization CD117/c-kit Antibody [Unconjugated]](http://images.novusbio.com/fullsize/antibody/af1356_human-mouse-cd117-c-kit-affinity-purified-polyclonal-ab-in-situ-hybridization-235202419324..jpg)
![Immunohistochemistry CD117/c-kit Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/CD117_AF332_Immunohistochemistry_17287.jpg)
![Western Blot CD117/c-kit Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/CD117_AF332_Western_Blot_18635.jpg)
![Simple Western CD117/c-kit Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/CD117_AF332_Simple_Western_17472.jpg)
![SDS-PAGE CD117/c-kit [Unconjugated]](http://images.novusbio.com/fullsize2/10961-sr_recombinant-human-cd117-c-kit-fc-chimera-protein-cf-sds-page-11112021133650.jpg)
![SDS-PAGE CD117/c-kit [Biotin]](http://images.novusbio.com/fullsize2/avi10703_recombinant-human-cd117-c-kit-fc-chimera-avi-tag-protein-cf-sds-page-422021104715.jpg)