CCR7 Antibody (150503) [Alexa Fluor® 700]

This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CCR7 (Chemokine Receptor 7; also CD197) is a 7 transmembrane (7TM) G protein-coupled chemokine receptor for the homeostatic chemokines CCL19/MIP-3 beta and CCL21/6Ckine. CCL19 and CCL21 are constitutively expressed by high endothelial venule epithelial cells or fibroblastic reticular cells in secondary lymphoid organs. CCR7 is upregulated on dendritic cells, naïve and memory T cells, Treg, NK cells, and B cells following inflammatory stimulation. Its expression enables the function of immune cell trafficking to and retention in regional lymph nodes for expansion of the adaptive immune response. Human CCR7 shares 87% amino acid sequence identity with mouse CCR7.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Primate - Macaca mulatta (Rhesus Macaque).

We have publications tested in 1 application: Flow Cytometry.

Showing Publications 1 - 3 of 3.

Publications using FAB197N	Applications	Species
Li H, Richert-Spuhler L, Evans T, Gillis J, Connole M, Estes J, Keele B, Klatt N, Reeves R Hypercytotoxicity and rapid loss of NKp44+ innate lymphoid cells during acute SIV infection. PLoS Pathog, 2014-12-11;10(12):e1004551. 2014-12-11 [PMID: 25503264] (Flow Cytometry, Primate - Macaca mulatta (Rhesus Macaque))	Flow Cytometry	Primate - Macaca mulatta (Rhesus Macaque)
Onabajo , Olusegun, George , Jeffy, Lewis , Mark G, Mattapallil , Joseph J Rhesus macaque lymph node PD-1(hi)CD4+ T cells express high levels of CXCR5 and IL-21 and display a CCR7(lo)ICOS+Bcl6+ T-follicular helper (Tfh) cell phenotype. PLoS ONE, 2013-03-19;8(3):e59758. 2013-03-19 [PMID: 23527264] (Flow Cytometry, Primate - Macaca mulatta (Rhesus Macaque))	Flow Cytometry	Primate - Macaca mulatta (Rhesus Macaque)
Biancotto A, Dagur PK, Fuchs JC, Wiestner A, Bagwell CB, McCoy JP Phenotypic complexity of T regulatory subsets in patients with B-chronic lymphocytic leukemia. Mod. Pathol., 2011-11-18;25(2):246-59. 2011-11-18 [PMID: 22101351] (Flow Cytometry, Human)	Flow Cytometry	Human

Array FAB197N

• CCR7 Antibodies
• CCR7 ELISA Kits
• CCR7 Lysate
• CCR7 Proteins