Caldesmon/CALD1 Antibody

Caldesmon is a smooth muscle and nonmuscle regulatory protein that interacts with actin, myosin, tropomyosin, and calmodulin (1,2). Smooth muscle caldesmon is an elongated molecule with a calmodulin, tropomyosin, and actin-binding region at the C-terminus and a myosin-binding domain at the N-terminus (3). Caldesmon stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, caldesmon inhibits the actomyosin ATPase by binding to F-actin. This inhibition is reduced by calcium-calmodulin and is promoted by tropomyosin (4).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: IF/IHC.

Showing Publications 1 - 4 of 4.

Publications using NBP1-85702	Applications	Species
Alexandre Calon, Enza Lonardo, Antonio Berenguer-Llergo et al. Stromal gene expression defines poor-prognosis subtypes in colorectal cancer. Nature Genetics 2015-02-23 [PMID: 25706628] (IF/IHC, Human)	IF/IHC	Human
Stadler C, Hjelmare M, Neumann B et al. Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy. J Proteomics 2012-04-03 [PMID: 22361696]
Fagerberg L, Stadler C, Skogs M et al. Mapping the subcellular protein distribution in three human cell lines. J Proteome Res 2011-08-01 [PMID: 21675716]
Kohler CN, et al. Histochemical localization of caldesmon in the CNS and ganglia of the mouse. J Histochem Cytochem 2011-05-01 [PMID: 21411712]

Array NBP1-85702

• Caldesmon/CALD1 Antibodies
• Caldesmon/CALD1 ELISA Kits
• Caldesmon/CALD1 Proteins