Cadherin-13 Antibody (392411) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Cadherin-13, also known as T-cadherin and H-cadherin, is a 105 kDa member of the cadherin family of transmembrane glycoproteins that mediate calcium-dependent intercellular adhesion (1). However, Cadherin-13 is an atypical member, lacking transmembrane and cytosolic domains and containing a GPI moiety that anchors Cadherin-13 to the plasma membrane (1‑2). Human Cadherin-13 is synthesized as a 713 amino acid (aa) precursor that contains a 22 aa signal sequence, a 116 aa propeptide, a 555 aa mature chain, and a second propeptide of 20 aa that is removed in the mature form to reveal the GPI anchor. The mature form contains five cadherin domains and eight potential sites for N-linked glycosylation. Mature human Cadherin-13 shares 96% aa identity with mature mouse Cadherin-13. Cadherin-13 is expressed in various tissues. It is highly expressed in the heart, and in the CNS, Cadherin-13 is expressed in the cerebral cortex, medulla, hippocampus, amygdala, thalamus, and substantia nigra (2). There are higher levels of Cadherin-13 in the adult brain than in developing brain (2). Cadherin-13 is also expressed in skin in the basal layer of the epidermis, lung, liver, kidney, and blood vessels (2). The structural characteristics of Cadherin-13 predict that it is unlikely to function as a true adhesion molecule in vivo (2). It is suggested that it may act rather as a signaling receptor participating in recognition of the environment and regulation of cell motility, proliferation, and phenotype (2). Cellular expression levels of Cadherin-13 in various tissues often correlate, negatively or positively, with the proliferative potential of the cells (2). Cadherin-13 may also act as a suppressor of tumor cell growth (2). This potential role for Cadherin-13 was emphasized by localization of Cadherin-13 gene to chromosome 16q24, a region exhibiting loss of heterozygosity in many solid tumors (2). Allelic loss of chromosome bands 16q24.1-q24.2 and reduced expression of Cadherin-13, as well as hypermethylation of the remaining allele have been detected in a considerable number of human cancers (2).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: IHC, Western Blot.

Showing Publications 1 - 3 of 3.

Publications using MAB3264	Applications	Species
M Norreen-Th, EC Struck, S Öling, M Zwahlen, K Von Feilit, J Odeberg, C Lindskog, F Pontén, M Uhlén, PJ Dusart, LM Butler A human adipose tissue cell-type transcriptome atlas Cell Reports, 2022-07-12;40(2):111046. 2022-07-12 [PMID: 35830816] (IHC, Human)	IHC	Human
TA Sakaue, Y Fujishima, Y Fukushima, Y Tsugawa-Sh, S Fukuda, S Kita, H Nishizawa, B Ranscht, K Nishida, N Maeda, I Shimomura Adiponectin accumulation in the retinal vascular endothelium and its possible role in preventing early diabetic microvascular damage Scientific Reports, 2022-03-09;12(1):4159. 2022-03-09 [PMID: 35264685] (Western Blot, Mouse)	Western Blot	Mouse
Matsuda , Keisuke, Fujishima , Yuya, Maeda , Norikazu, Mori , Takuya, Hirata , Ayumu, Sekimoto , Ryohei, Tsushima , Yu, Masuda , Shigeki, Yamaoka , Masaya, Inoue , Kana, Nishizawa , Hitoshi, Kita , Shunbun, Ranscht , Barbara, Funahashi , Tohru, Shimomura , Iichiro Positive feedback regulation between adiponectin and T-cadherin impacts adiponectin levels in tissue and plasma of male mice. Endocrinology, 2014-12-16;156(3):934-46. 2014-12-16 [PMID: 25514086] (IHC, Western Blot, Mouse)	IHC, Western Blot	Mouse

Array MAB3264

• Cadherin-13 Antibodies
• Cadherin-13 ELISA Kits
• Cadherin-13 Lysate
• Cadherin-13 Protein
• Cadherin-13 Proteins and Enzymes