BRCA1 Antibody (440621) [Unconjugated] - C-terminus

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

The BRCA1 (BReast CAncer gene 1) tumor suppressor protein has many reported functions. In addition to mediating signal transduction in DNA damage and repair responses, BRCA1 forms a heterodimer with BARD1 and regulates transcriptional activity, assisting in the preservation of chromosomal stability. BRCA1 is one of the first proteins recruited to sites of DNA double-strand breaks and serves as part of a scaffold for assembling other DNA damage response or repair factors, including MSH2, MLH1, ATM and PMS2.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: Flow Cytometry, Immunoprecipitation, Western Blot.

Showing Publications 1 - 10 of 11. Show All 11 Publications. Collapse Publications.

Publications using MAB22101	Applications	Species
Guo Y, Chomiak AA, Hong Y et al. Histone H2A ubiquitination resulting from Brap loss of function connects multiple aging hallmarks and accelerates neurodegeneration iScience 7/15/2022 [PMID: 35754718]
Chomiak AA, Guo Y, Kopsidas CA et al. Nde1 is required for heterochromatin compaction and stability in neocortical neurons iScience 2022-06-17 [PMID: 35601919]
Z Mirman, NK Sasi, A King, JR Chapman, T de Lange 53BP1-shieldin-dependent DSB processing in BRCA1-deficient cells requires CST-Polalpha-primase fill-in synthesis Nature Cell Biology, 2022-01-13;24(1):51-61. 1/13/2022 [PMID: 35027730]
J Yang, L Qi, HC Chiang, B Yuan, R Li, Y Hu BRCA1 Antibodies Matter International journal of biological sciences, 2021-07-25;17(12):3239-3254. 2021-07-25 [PMID: 34421362] (Immunoprecipitation, Western Blot, Human, Mouse)	Immunoprecipitation, Western Blot	Human, Mouse
Mirman Z, Lottersberger F, Takai H et al. 53BP1-RIF1-shieldin counteracts DSB resection through CST-and Pola-dependent fill-in. Nature. 7/18/2018 [PMID: 30022158]
Silvia Maifrede, Margaret Nieborowska-Skorska, Katherine Sullivan-Reed, Yashodhara Dasgupta, Paulina Podszywalow-Bartnicka, Bac Viet Le et al. Tyrosine kinase inhibitor–induced defects in DNA repair sensitize FLT3(ITD)-positive leukemia cells to PARP1 inhibitors Blood 2018-07-05 [PMID: 29784639]
S Maifrede, K Martin, P Podszywalo, K Sullivan, SK Langer, R Nejadi, Y Dasgupta, M Hulse, D Gritsyuk, M Nieborowsk, LN Lupey-Gree, H Zhao, K Piwocka, MA Wasik, I Tempera, T Skorski IGH/MYC Translocation Associates with BRCA2 Deficiency and Synthetic Lethality to PARP1 Inhibitors Mol. Cancer Res., 2017-06-20;0(0):. 2017-06-20 [PMID: 28634224] (Flow Cytometry, Western Blot, Human)	Flow Cytometry, Western Blot	Human
M Nieborowsk, K Sullivan, Y Dasgupta, P Podszywalo, G Hoser, S Maifrede, E Martinez, D Di Marcant, E Bolton-Gil, K Cramer-Mor, J Lee, M Li, A Slupianek, D Gritsyuk, S Cerny-Reit, I Seferynska, T Stoklosa, L Bullinger, H Zhao, V Gorbunova, K Piwocka, P Valent, CI Civin, M Muschen, JE Dick, JC Wang, S Bhatia, R Bhatia, K Eppert, MD Minden, SM Sykes, T Skorski Gene expression and mutation-guided synthetic lethality eradicates proliferating and quiescent leukemia cells J. Clin. Invest., 2017;127(6):2392-2406. 2017 [PMID: 28481221] (Western Blot, Human)	Western Blot	Human
Aaron M. Shapiro, Lutfiya Miller-Pinsler, Peter G. Wells Breast cancer 1 (BRCA1)-deficient embryos develop normally but are more susceptible to ethanol-initiated DNA damage and embryopathies☆ Redox Biology 2016-04-01 [PMID: 26629949]
Shinji Kawai, Atsuo Amano BRCA1 regulates microRNA biogenesis via the DROSHA microprocessor complex Journal of Cell Biology 2012-04-16 [PMID: 22492723]
Wolanin K, Magalska A, Kusio-Kobialka M, Podszywalow-Bartnicka P, Vejda S, McKenna SL, Mosieniak G, Sikora E, Piwocka K Expression of oncogenic kinase Bcr-Abl impairs mitotic checkpoint and promotes aberrant divisions and resistance to microtubule-targeting agents. Mol. Cancer Ther., 2010-05-04;9(5):1328-38. 2010-05-04 [PMID: 20442314] (Western Blot, Mouse)	Western Blot	Mouse
Show All 11 Publications. Collapse Publications.

Array MAB22101

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