BP1 Antibody

BP1 (beta protein 1; also called distal-less homeobox gene 4 or DLX4) is a member of DLX family of homeobox genes and it controls many aspects of embryonic development including bone morphogenesis, skeletal patterning and cell differentiation. Originally discovered to be a repressor of beta-globin gene in erythroid cells, BP1 is normally expressed during early hematopoiesis with complete absence from most normal adult tissues and is widely re-expressed in leukemias, lung, breast, ovarian as well as prostate cancers. BP1 is an oncogene with a major role in breast cancer, and that its expression correlates with breast cancer progression and invasion. BP1 has been found to be detectable in 80% of infiltrating ductal carcinomas, but undetectable in matched normal controls, being the first DLX gene to be strongly implicated in breast cancer. Furthermore, expression of DLX4 correlates with estrogen receptor status and also cancer progression and invasion in breast cancer.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 3 applications: Chemotaxis, IF/IHC, WB.

Showing Publications 1 - 7 of 7.

Publications using NB100-481	Applications	Species
Zhou JD, Zhao YJ, Leng JY et al. DNA methylation-mediated differential expression of DLX4 isoforms has opposing roles in leukemogenesis Cellular & molecular biology letters 2022-07-26 [PMID: 35883028] (WB, Chemotaxis, Human)	WB, Chemotaxis	Human
Jeong J, Naab TJ, Fernandez AI et al. Homeoprotein DLX4 expression is increased in inflammatory breast cancer cases from an urban African-American population Oncotarget 2018-07-27 [PMID: 30131852] (IF/IHC, Human)	IF/IHC	Human
Kluk BJ, Fu Y, Formolo TA et al. BP1, an isoform of DLX4 homeoprotein, negatively regulates BRCA1 in sporadic breast cancer. Int J Biol Sci 2010-09-10 [PMID: 20877436] (WB, Human)	WB	Human
Fu Y, Lian Y, Kim KS et al. BP1 Homeoprotein Enhances Metastatic Potential in ER-negative Breast Cancer. J Cancer 2010-06-24 [PMID: 20842225] (WB, Human)	WB	Human
Yin J, Wei ZJ, Li KB et al. Identification and molecular characterization of a new member of the peritrophic membrane proteins from the meadow moth, loxostege sticticalis. Int J Biol Sci;6(5):491-8. 2010-09-06 [PMID: 20827401]
Song Y, Dang C, Fu Y W et al. Genome-wide analysis of BP1 transcriptional targets in breast cancer cell line Hs578T. Int J Biol Sci 2009-01-01 [PMID: 19119308] (WB, Human)	WB	Human
Stevenson, HS et al. BP1 transcriptionally activates bcl-2 and inhibits TNFalpha-induced cell death in MCF7 breast cancer cells. Breast Cancer Res;9(5):R60. 2007-01-01 [PMID: 17854498] (WB, Human)	WB	Human

Images	Ratings	Applications	Species	Date	Details
	4 reviewed by: Patricia Berg	WB	Human	08/10/2010	View Summary Application Western Blot Sample Tested whole cell lysate, Sample Amount: 10-20ug/well Species Human

Array NB100-481

• BP1 Antibodies
• BP1 Lysates
• BP1 Protein