BMP-7 Antibody (164311) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Bone morphogenetic protein 7 (BMP-7), also known as osteogenic protein 1 (OP-1), is a widely expressed TGF-beta superfamily member with important functions during embryogenesis, in the adult, and in disease (1, 2). Human BMP-7 is synthesized with a 29 amino acid (aa) signal sequence, a 263 aa propeptide, and a 139 aa growth factor domain (3, 4). The growth factor domain of human BMP-7 shares 98% aa sequence identity with mouse and rat BMP-7. The BMP-7 propeptide is cleaved intracellularly but often remains associated with the mature C-terminus. Based on in vivo and in vitro studies, BMP-7 has the potential to be secreted as a disulfide‑linked mature homodimer, or particularly as a heteromeric complex that consists of two propeptides noncovalently associated with a mature disulfide‑linked homodimer (5, 6). The presence of the propeptides in BMP-7 appears to stabilize the molecule and provide a docking mechanism for extracellular storage on molecules such as fibrillin-1 and -2 (5, 6). The propeptides themselves do not impart latency to the complex. BMP-7 binding to type II receptors rapidly displaces the prodomain:mature molecule interaction and has no effect on activity. But it is suggested that immobilized BMP-7 (via prodomain:fibrillin) is inactive, allowing for possible long-term storage of the molecule (6). BMP-7 interacts with the type 2 receptors Activin RIIA, Activin RIIB, and BMPR-II and the type 1 receptors Activin RIA, BMPR-IA, and BMPR-IB (2, 6). BMP-7 may also be processed into a disulfide‑linked heterodimer with either BMP-2 or BMP-4. Such complexes may show increased potency and range of activity compared to BMP-7 homodimers (7‑9). BMP-7 plays a role in a variety of organ systems. It promotes new bone formation and nephron development (10, 11), inhibits the branching of prostate epithelium (12), and antagonizes epithelial-mesenchymal transition (EMT) (13‑15). In pathological conditions, BMP-7 inhibits tumor growth and metastasis (14), ameliorates fibrotic damage in nephritis (13), and promotes neuroregeneration following brain ischemia (16).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Hamster.

We have publications tested in 8 applications: ELISA, ELISA Development, ICC, IHC, IHC-P, Immunoprecipitation, Neutralization, Western Blot.

Showing Publications 1 - 10 of 11. Show All 11 Publications. Collapse Publications.

Publications using MAB3541	Applications	Species
R Oude Egber, HM Zegelaar, N El Boujnou, EMM Versteeg, WF Daamen, R Brock Biomaterial-Mediated Protein Expression Induced by Peptide-mRNA Nanoparticles Embedded in Lyophilized Collagen Scaffolds Pharmaceutics, 2022-08-02;14(8):. 2022-08-02 [PMID: 36015245] (ELISA, Mouse)	ELISA	Mouse
MG Kim, CL Kim, YS Kim, JW Jang, GM Lee Selective endocytosis of recombinant human BMPs through cell surface heparan sulfate proteoglycans in CHO cells: BMP-2 and BMP-7 Scientific Reports, 2021-02-09;11(1):3378. 2021-02-09 [PMID: 33564092] (ICC, Western Blot, Hamster)	ICC, Western Blot	Hamster
V Veschi, LR Mangiapane, A Nicotra, S Di Franco, E Scavo, T Apuzzo, DS Sardina, M Fiori, A Benfante, ML Colorito, G Cocorullo, F Giuliante, C Cipolla, G Pistone, MR Bongiorno, A Rizzo, CM Tate, X Wu, S Rowlinson, LF Stancato, M Todaro, R De Maria, G Stassi Targeting chemoresistant colorectal cancer via systemic administration of a BMP7 variant Oncogene, 2019-10-07;0(0):. 2019-10-07 [PMID: 31591478] (ICC, IHC-P, Human)	ICC, IHC-P	Human
N Blanchette, D Kita, A Konstorum, L Tesfay, D Lemler, P Hegde, KP Claffey, FM Torti, SV Torti Contribution of three-dimensional architecture and tumor-associated fibroblasts to hepcidin regulation in breast cancer Oncogene, 2018-04-26;37(29):4013-4032. 2018-04-26 [PMID: 29695834] (Neutralization, Human)	Neutralization	Human
Ashish Tandon, Ajay Sharma, Jason T. Rodier, Alexander M. Klibanov, Frank G. Rieger, Rajiv R. Mohan BMP7 Gene Transfer via Gold Nanoparticles into Stroma Inhibits Corneal Fibrosis In Vivo PLoS ONE 2013-06-14 [PMID: 23799103]
Yinan Liu, Jinfeng Chen, Yue Yang, Lijian Zhang, Wen G Jiang Μolecular impact of bone morphogenetic protein�7, on lung cancer cells and its clinical significance International Journal of Molecular Medicine 2012-03-23 [PMID: 22447022]
Du Y, Xiao Q, Yip HK Regulation of retinal progenitor cell differentiation by bone morphogenetic protein 4 is mediated by the smad/id cascade. Invest. Ophthalmol. Vis. Sci., 2010-02-03;51(7):3764-73. 2010-02-03 [PMID: 20130285] (IHC, Western Blot, Mouse)	IHC, Western Blot	Mouse
Sengle G, Ono RN, Lyons KM, Bachinger HP, Sakai LY A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7. J. Mol. Biol., 2008-07-02;381(4):1025-39. 2008-07-02 [PMID: 18621057] (ELISA Development, Human)	ELISA Development	Human
Hsu MY, Rovinsky SA, Lai CY, Qasem S, Liu X, How J, Engelhardt JF, Murphy GF Aggressive melanoma cells escape from BMP7-mediated autocrine growth inhibition through coordinated Noggin upregulation. Lab. Invest., 2008-06-16;88(8):842-55. 2008-06-16 [PMID: 18560367] (IHC-P, Human)	IHC-P	Human
Sengle G, Charbonneau NL, Ono RN, Sasaki T, Alvarez J, Keene DR, Bachinger HP, Sakai LY Targeting of bone morphogenetic protein growth factor complexes to fibrillin. J. Biol. Chem., 2008-03-13;283(20):13874-88. 2008-03-13 [PMID: 18339631] (Western Blot, Human)	Western Blot	Human
Zhao M, Zhao Z, Koh JT, Jin T, Franceschi RT Combinatorial gene therapy for bone regeneration: cooperative interactions between adenovirus vectors expressing bone morphogenetic proteins 2, 4, and 7. J. Cell. Biochem., 2005-05-01;95(1):1-16. 2005-05-01 [PMID: 15759283] (Immunoprecipitation, Mouse)	Immunoprecipitation	Mouse
Show All 11 Publications. Collapse Publications.

Array MAB3541

• BMP-7 Antibodies
• BMP-7 ELISA Kits
• BMP-7 Lysate
• BMP-7 Proteins
• BMP-7 ELISAs
• BMP-7 Proteins and Enzymes