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beta-2 Adrenergic R/ADRB2 Antibody (4C11)

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Immunohistochemistry: beta-2 Adrenergic R/ADRB2 Antibody (4C11) [NBP3-26521] - Image of beta-2 Adrenergic R/ADRB2 Antibody (4C11) diluted at 1:100 and staining in paraffin-embedded human endometrial cancer performed. ...read more
Immunohistochemistry: beta-2 Adrenergic R/ADRB2 Antibody (4C11) [NBP3-26521] - Image of beta-2 Adrenergic R/ADRB2 Antibody (4C11) diluted at 1:100 and staining in paraffin-embedded human endometrial cancer performed. ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA, IHC
Clone
4C11
Clonality
Monoclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

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beta-2 Adrenergic R/ADRB2 Antibody (4C11) Summary

Additional Information
Recombinant monoclonal antibody expressed in HEK293F cells
Immunogen
A synthesized peptide derived from Human beta-2 Adrenergic R/ADRB2 [UniProt P07550]
Isotype
IgG
Clonality
Monoclonal
Host
Rabbit
Gene
ADRB2
Purity
Affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • ELISA
  • Immunohistochemistry 1:50-1:200

Packaging, Storage & Formulations

Storage
Store at -20 to -70C. Avoid freeze-thaw cycles.
Buffer
PBS, pH 7.4, 150mM NaCl and 50% glycerol
Preservative
0.02% Sodium Azide
Purity
Affinity purified

Alternate Names for beta-2 Adrenergic R/ADRB2 Antibody (4C11)

  • ADRB2
  • ADRB2R
  • ADRBR
  • adrenergic, beta-2-, receptor, surface
  • B2AR
  • B2ARADRB2R
  • BAR
  • beta-2 Adrenergic R
  • beta-2 adrenergic receptor
  • beta2 AdrenergicR
  • beta-2 AdrenergicR
  • Beta-2 adrenoceptor
  • Beta-2 adrenoreceptor
  • BETA2AR
  • catecholamine receptor

Background

The beta-2 adrenoceptor (ADRB2) is an Adrenergic Receptor expressed in smooth muscle and metabolic tissues. Activation of this receptor induces a decrease in gastrointestinal motility, bronchodilation, vasodilation in skeletal and cardiac muscle, and glycogenolysis in liver. The beta-2 adrenoceptor is also a major lipolytic receptor in human fat cells and may be involved in obesity. Agonists of ADRB2 are most widely used for the treatment of asthma. In complex with beta-arrestin-1 and c-src, the beta-2 adrenergic receptor activates MAP kinases ERK1(MAPK3) and ERK2 (MAPK1). Expression of the beta-2 adrenoceptor has been reported in adipose, blood, brain, heart, lung, nose, pancreas, skeletal muscle, skin, and vessel. ESTs have been isolated from breast, liver, liver/spleen, placenta, and uterus libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol ADRB2