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beta-2 Adrenergic R/ADRB2 Antibody (13D6) [mFluor Violet 450 SE]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA, ICC/IF, IP
Clone
13D6
Clonality
Monoclonal
Host
Rabbit
Conjugate
mFluor Violet 450 SE

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP3-12008AF350
Alexa Fluor 405
NBP3-12008AF405
Alexa Fluor 488
NBP3-12008AF488
Alexa Fluor 532
NBP3-12008AF532
Alexa Fluor 594
NBP3-12008AF594
Alexa Fluor 647
NBP3-12008AF647
Alexa Fluor 700
NBP3-12008AF700
Alexa Fluor 750
NBP3-12008AF750
Biotin
NBP3-12008B
CoraFluor 1
NBP3-12008CL1
DyLight 350
NBP3-12008UV
DyLight 405
NBP3-12008V
DyLight 488
NBP3-12008G
DyLight 550
NBP3-12008R
DyLight 594
NBP3-12008DL594
DyLight 650
NBP3-12008C
DyLight 680
NBP3-12008FR
DyLight 755
NBP3-12008IR
FITC
NBP3-12008F
HRP
NBP3-12008H
Janelia Fluor 525
NBP3-12008JF525
Janelia Fluor 549
NBP3-12008JF549
Janelia Fluor 585
NBP3-12008JF585
Janelia Fluor 635
NBP3-12008JF635
Janelia Fluor 646
NBP3-12008JF646
Janelia Fluor 669
NBP3-12008JF669
PerCP
NBP3-12008PCP
Unconjugated
NBP3-12008-0.2mg
mFluor Violet 500 SE
NBP3-12008MFV500
mFluor Violet 610 SE
NBP3-12008MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP3-12008-0.2mg
Azide and BSA Free
NBP3-12008-0.2mg
Azide and BSA Free
NBP3-12008-0.025mg
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beta-2 Adrenergic R/ADRB2 Antibody (13D6) [mFluor Violet 450 SE] Summary

Additional Information
Recombinant Monoclonal Antibody
Immunogen
This antibody was raised by immunizing mice with beta-2 adrenergic receptor.
Specificity
13D6 antibody recognizes human beta-2 adrenergic receptor. It was reported that this antibody recognizes extracellualr domains of the receptor (Han et al., 2012). Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds adrenaline with far grater affinity than noradrenaline.
Isotype
IgG Kappa
Clonality
Monoclonal
Host
Rabbit
Gene
ADRB2
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Immunoprecipitation
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A purified

Notes

mFluor(TM) is a trademark of AAT Bioquest, Inc. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for beta-2 Adrenergic R/ADRB2 Antibody (13D6) [mFluor Violet 450 SE]

  • ADRB2
  • ADRB2R
  • ADRBR
  • adrenergic, beta-2-, receptor, surface
  • B2AR
  • B2ARADRB2R
  • BAR
  • beta-2 Adrenergic R
  • beta-2 adrenergic receptor
  • beta2 AdrenergicR
  • beta-2 AdrenergicR
  • Beta-2 adrenoceptor
  • Beta-2 adrenoreceptor
  • BETA2AR
  • catecholamine receptor

Background

The beta-2 adrenoceptor (ADRB2) is an Adrenergic Receptor expressed in smooth muscle and metabolic tissues. Activation of this receptor induces a decrease in gastrointestinal motility, bronchodilation, vasodilation in skeletal and cardiac muscle, and glycogenolysis in liver. The beta-2 adrenoceptor is also a major lipolytic receptor in human fat cells and may be involved in obesity. Agonists of ADRB2 are most widely used for the treatment of asthma. In complex with beta-arrestin-1 and c-src, the beta-2 adrenergic receptor activates MAP kinases ERK1(MAPK3) and ERK2 (MAPK1). Expression of the beta-2 adrenoceptor has been reported in adipose, blood, brain, heart, lung, nose, pancreas, skeletal muscle, skin, and vessel. ESTs have been isolated from breast, liver, liver/spleen, placenta, and uterus libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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beta-2 Adrenergic
R/ADRB2 Antibody (13D ...
NBP3-12008MFV450
beta-2 Adrenergic R/ADRB2 Antibody (13D6) [mFluor Violet 450 SE]
Species: Hu
Applications: WB, ELISA, ICC/IF, IP

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mFluor Violet Conjugated Antibodies

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Bioinformatics

Gene Symbol ADRB2