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beta-1,3-Glucuronyltransferase 1/B3GAT1 Antibody [DyLight 550]

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Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications ICC/IF, IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
DyLight 550

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beta-1,3-Glucuronyltransferase 1/B3GAT1 Antibody [DyLight 550] Summary

Immunogen
A synthetic peptide made to a C-terminal portion of the human B3GAT1 protein (between residues 250-300) [UniProt Q9P2W7]
Localization
Golgi apparatus membrane; Single-pass type II membrane protein.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
B3GAT1
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for beta-1,3-Glucuronyltransferase 1/B3GAT1 Antibody [DyLight 550]

  • B3GAT1
  • beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)
  • Beta-1,3-glucuronyltransferase 1
  • CD57
  • EC 2.4.1.135
  • galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1
  • GLCATP
  • GlcAT-P
  • GLCATPGLCUATP
  • GLCUATP
  • glcUAT-P
  • Glucuronosyltransferase P
  • HNK1
  • LEU7
  • NK1
  • NK-1
  • UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase

Background

CD57 (also known as beta-1,3-glucuronyltransferase 1, Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1, Glucuronosyltransferase P, Human Natural Killer 1, B3GAT1, NK1, HNK1, LEU7, NK-1, GLCUATP, and GLCATP) is a member of the glucuronyltransferase gene family. The enzymes produced by the members of this family recognize non-reducing terminal sugars and their anomeric linkages by exhibiting strong acceptor specificity. CD57 is also involved in the biosynthesis of glycosaminoglycan and L2/HNK-1 carbohydrate epitopes on glycoproteins. CD57 is expressed mainly in the brain and several alternate transcriptional splice variants have been characterized. In cancer research, CD57 positive lymphocytes have been used successfully in monitoring the progression of various cancers (PMID: 21491089). HNK1 is also involved in synaptic plasticity and neurodevelopment (PMID: 20950796).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol B3GAT1