ARNT/HIF-1 beta Antibody

Aryl hydrocarbon nuclear translocator (ARNT), also commonly known as Hypoxia-inducible factor 1-beta (HIF-1 beta), is a ubiquitously expressed transcription factor that is part of the basic-helix-loop-helix (bHLH)-Per-ARNT-Sim (PAS) family (1, 2). Human arnt is located on chromosome 1q21 and encodes a protein 789 amino acids (aa) in length with a theoretical molecular weight of 87 kDa (1). Structurally, ARNT has a DNA binding bHLH domain, two PAS domains required for dimerization, and a transactivation domain/PAC region (1). ARNT belongs to the Class II bHLH-PAS proteins and is able to homodimerize or heterodimerize with the Class I proteins including AHA, AHRR, HIF-1 alpha, HIF-2 alpha, NPAS1, and SIM1 (2). Dimerization allows for efficient DNA binding and regulation of their target genes (2).

ARNT has an important role in two specific signaling pathways - the aryl hydrocarbon receptor (AhR) and the hypoxia inducible factor (HIF) pathway (1). In the AhR pathway, AhR in the cytosol is typically inactive and bound to heat shock protein 90 (hsp90) (3). Upon activation and ligand binding by environmental pollutants such as dioxins, AhR is translocated to the nucleus, dissociates from hsp90, and dimerizes with ARNT, leading to binding to response elements and expression of target genes including monooxygenases (1, 3). In the HIF pathway, under hypoxia (low oxygen) conditions prolylhydroxylase domain (PHD) enzymes and factor inhibiting HIF (FIH) are inhibited. HIF-1 alpha (or HIF-2 alpha) accumulates and is transported to the nucleus where it heterodimerizes with ARNT, allowing for binding to target gene's hypoxia response element (HRE), recruitment of coactivators, and transcription (1, 3). HIF-induced gene transcription plays a large role in tumor progression by promoting invasion, metastasis, de-differentiation and altered metabolism, and angiogenesis (1). While HIF-1 alpha's stability is dependent upon oxygen conditions, HIF-1 beta is stable in both normoxia and hypoxia (1-3).

The bHLH-PAS family and ARNT have been linked with a variety of pathologies and diseases including cancer, metabolic diseases, autoimmune diseases, and psychiatric disorders (2). ARNT/AHR is expressed in the skin and its pathway activation enhances skin barrier function and epidermal terminal differentiation, thus AHR agonists are currently being used as therapeutics for atopic dermatitis and psoriasis (4). Accordingly, studies of Arnt-deficient mice show profound abnormalities in skin barrier function and keratinization (4). Additionally, studies suggest that ARNT plays an important role in diabetes and beta-cell function (5). Islets from patients with type 2 diabetes have a significantly decreased ARNT expression compared to glucose-tolerant control donors (5). Modulation and stimulation of the HIF pathway may be a potential therapeutic strategy for treating type 2 diabetes and metabolic syndrome (5).

Alternate names for ARNT/HIF-1 beta include aryl hydrocarbon receptor nuclear translocator, BHLHE2, class E basic helix-loop-helix protein 2, Dixon receptor nuclear translocator, Hypoxia-inducible factor 1-beta, nuclear translocator, and TANGO.

References

1. Mandl, M., & Depping, R. (2014). Hypoxia-inducible aryl hydrocarbon receptor nuclear translocator (ARNT) (HIF-1beta): is it a rare exception?. Molecular medicine (Cambridge, Mass.). https://doi.org/10.2119/molmed.2014.00032

2. Wu, D., & Rastinejad, F. (2017). Structural characterization of mammalian bHLH-PAS transcription factors. Current opinion in structural biology. https://doi.org/10.1016/j.sbi.2016.09.011

3. Esser, C., & Rannug, A. (2015). The aryl hydrocarbon receptor in barrier organ physiology, immunology, and toxicology. Pharmacological reviews.https://doi.org/10.1124/pr.114.009001

4. Furue, M., Hashimoto-Hachiya, A., & Tsuji, G. (2019). Aryl Hydrocarbon Receptor in Atopic Dermatitis and Psoriasis. International journal of molecular sciences. https://doi.org/10.3390/ijms20215424

5. Girgis, C. M., Cheng, K., Scott, C. H., & Gunton, J. E. (2012). Novel links between HIFs, type 2 diabetes, and metabolic syndrome. Trends in endocrinology and metabolism: TEM, https://doi.org/10.1016/j.tem.2012.05.003

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 6 confirmed species: Human, Mouse, Rat, Bovine, Canine, Fish.

We have publications tested in 9 applications: ChIP, Chemotaxis, EMSA, IB, ICC/IF, IF/IHC, IHC-P, IP, WB.

Showing Publications 1 - 10 of 73. Show All 73 Publications. Collapse Publications.

Publications using NB100-110	Applications	Species
Naas S, Krüger R, Knaup KX et al. Hypoxia controls expression of kidney-pathogenic MUC1 variants Life science alliance 2023-09-01 [PMID: 37316299] (ChIP, Human)	ChIP	Human
Grampp S, Krüger R, Lauer V et al. Hypoxia hits APOL1 in the kidney Kidney international 2023-04-23 [PMID: 37098381] (Human)		Human
Zuo Q, Yang Y, Lyu Y, Yang C, Chen C, Salman S, Huang T, Wicks E, Jackson W, Datan E, Qin W, Semenza G Plexin-B3 expression stimulates MET signaling, breast cancer stem cell specification, and lung metastasis. Cell Rep, 2023-02-28;42(3):112164. 2023-02-28 [PMID: 36857181]
Lafleur VN, Halim S, Choudhry H et al. Multi-level interaction between HIF and AHR transcriptional pathways in kidney carcinoma Life science alliance 2023-04-01 [PMID: 36725335] (IP, ChIP, Human, Mouse)	IP, ChIP	Human, Mouse
Lauer V. Funktionsanalyse eines neuen, HIF-regulierten, nicht-kodierenden RNA-Transkripts Thesis 2017-01-01
Lyu Y, Yang Y, Talwar V et al Hypoxia-inducible factor 1 recruits FACT and RNF20/40 to mediate histone ubiquitination and transcriptional activation of target genes Cell Rep 2024-03-22 [PMID: 38517892] (ChIP, Human)	ChIP	Human
Grampp S, Kraus A, Skoczynski K et al. Hypoxia induces polycystin-1 expression in the renal epithelium Royal Society Open Science 2023-05-17 [PMID: 37206967]
Yang Y, Chen C, Zuo Q Et al. NARF is a hypoxia-induced coactivator for OCT4-mediated breast cancer stem cell specification Sci Adv 2022-12-09 [PMID: 36490339] (Chemotaxis, Human) Details: Citation using the DyLight 405 version of this antibody.	Chemotaxis	Human
Lombardi O, Li R, Halim S et al. Pan-cancer analysis of tissue and single-cell HIF-pathway activation using a conserved gene signature Cell Reports 2022-11-15 [PMID: 36384128] (WB)	WB
Salman S, Meyers DJ, Wicks EE Et al. HIF inhibitor 32-134D eradicates murine hepatocellular carcinoma in combination with anti-PD1 therapy J Clin Invest 2022-05-02 [PMID: 35499076] (Chemotaxis, Human) Details: Citation using the Alexa Fluor 488 version of this antibody.	Chemotaxis	Human
Protze J, Naas S, Kruger R et al. The renal cancer risk allele at 14q24.2 activates a novel hypoxia-inducible transcription factor-binding enhancer of DPF3 expression The Journal of biological chemistry 2022-02-08 [PMID: 35148991] (Chemotaxis, Human)	Chemotaxis	Human
Yang Y, Lu H, Chen C et al. HIF-1 Interacts with TRIM28 and DNA-PK to release paused RNA polymerase II and activate target gene transcription in response to hypoxia Nature communications 2022-01-14 [PMID: 35031618] (WB, Chemotaxis)	WB, Chemotaxis
Sasagawa T, Nagamatsu T, Yanagisawa M Et al. Hypoxia-inducible factor-1 beta is essential for upregulation of the hypoxia-induced FLT1 gene in placental trophoblasts Molecular human reproduction 2021-10-19 [PMID: 34665260] (WB, Human)	WB	Human
Haiquan Lu, Yajing Lyu, Linh Tran, Jie Lan, Yangyiran Xie, Yongkang Yang, Naveena L Murugan, Yueyang J Wang, Gregg L Semenza HIF-1 recruits NANOG as a coactivator for TERT gene transcription in hypoxic breast cancer stem cells. Cell reports 2022-02-10 [PMID: 34592152]
Wang J, Liu R, Wang Y Et Al. Repression of the miR-627-5p by histone deacetylase 3 contributes to hypoxia-induced hepatocellular carcinoma progression J Cancer 2021-08-02 [PMID: 34335948] (Chemotaxis)	Chemotaxis
Zeng Z, Shi Z, Liu Y et al. HIF-1 alpha-activated TM4SF1-AS1 promotes the proliferation, migration, and invasion of hepatocellular carcinoma cells by enhancing TM4SF1 expression Biochemical and biophysical research communications 2021-06-09 [PMID: 34118595]
Wang R, Godet I, Yang Y, et al. Hypoxia-inducible factor-dependent ADAM12 expression mediates breast cancer invasion and metastasis Proc Natl Acad Sci 2021-05-11 [PMID: 33952697] (Chemotaxis, WB)	Chemotaxis, WB
Seok S, Sun H, Kim YC, et al. Defective FXR-SHP Regulation in Obesity Aberrantly Increases miR-802 Expression, Promoting Insulin Resistance and Fatty Liver Diabetes 2020-12-16 [PMID: 33328206]
Orlando IMC, Lafleur VN, Storti F et al. Distal and proximal hypoxia response elements cooperate to regulate organ-specific erythropoietin gene expression Haematologica 2019-12-19 [PMID: 33256376]
Xin X, Kumar V, Lin F et al. Redox-responsive nanoplatform for codelivery of miR-519c and gemcitabine for pancreatic cancer therapy Sci Adv 2020-11-01 [PMID: 33177098] (WB, Human) Details: Western blot analysis performed in MIA PaCa-2 and HDPE cell lines.	WB	Human
Safi W, Kraus A, Grampp S et al. Macrophage migration inhibitory factor is regulated by HIF-1 alpha and cAMP and promotes renal cyst cell proliferation in a macrophage-independent manner J. Mol. Med. 2020-09-04 [PMID: 32885302] (Chemotaxis, WB, Canine)	Chemotaxis, WB	Canine
Ma X, Gao F, Chen Q et al. ACE2 modulates glucose homeostasis through GABA signaling during metabolic stress J. Endocrinol. 2020-09-01 [PMID: 32698150]
Ho JJD, Balukoff NC, Theodoridis PR et al. A network of RNA-binding proteins controls translation efficiency to activate anaerobic metabolism Nat Commun 2020-05-29 [PMID: 32472050] (WB, Human) Details: Citation using the HRP format of this antibody.	WB	Human
Lu H, Xie Y, Tran L et al. Chemotherapy-induced S100A10 recruits KDM6A to facilitate OCT4-mediated breast cancer stemness J Clin Invest. 2020-05-19 [PMID: 32427586] (Chemotaxis, Human)	Chemotaxis	Human
Chen J, Haller CA, Jernigan FE et al. Modulation of lymphocyte-mediated tissue repair by rational design of heterocyclic aryl hydrocarbon receptor agonists Sci Adv 2020-01-01 [PMID: 31998845] (WB, Mouse)	WB	Mouse
Niu Y, Bao L, Chen Y et al. HIF-2-induced long non-coding RNA RAB11B-AS1 promotes hypoxia-mediated angiogenesis and breast cancer metastasis Cancer Res. 2020-01-03 [PMID: 31900259] (WB, Chemotaxis, Mouse, Human)	WB, Chemotaxis	Mouse, Human
Wierenga ATJ, Cunningham A, Erdem A et al. HIF1/2-exerted control over glycolytic gene expression is not functionally relevant for glycolysis in human leukemic stem/progenitor cells Cancer & Metabolism 2019-12-27 [PMID: 31890203]
Orlando IMC, Lafleur VN, Storti F, et al. Distal and proximal hypoxia response elements cooperate to regulate organ-specific erythropoietin gene expression Haematologica 2019-12-19 [PMID: 31857363] (Chemotaxis, Human)	Chemotaxis	Human
Schultz E, Jones T, Clamp H, Barr K Co-incidence of RCC-susceptibility polymorphisms with HIF cis-acting sequences supports a pathway tuning model of cancer Sci Rep 2019-12-10 [PMID: 31822727] (Chemotaxis, Human)	Chemotaxis	Human
Lauer V, Grampp S, Platt J et al. Hypoxia drives glucose transporter 3 expression through HIF-mediated induction of the long non-coding RNA NICI J. Biol. Chem. 2019-11-05 [PMID: 31690629]
Osawa T, Shimamura T, Saito K et al. Phosphoethanolamine Accumulation Protects Cancer Cells under Glutamine Starvation through Downregulation of PCYT2 Cell Reports 2019-10-01 [PMID: 31577958] (WB, Human)	WB	Human
Louphrasitthiphol P, Ledaki I, Chauhan J, et al. MITF controls the TCA cycle to modulate the melanoma hypoxia response Pigment Cell Melanoma Res 2019-06-17 [PMID: 31207090] (Chemotaxis)	Chemotaxis
Smythies JA, Sun M, Masson N et al. Inherent DNA-binding specificities of the HIF-1a and HIF-2a transcription factors in chromatin. EMBO Rep. 2019-01-01 [PMID: 30429208] (WB, Chemotaxis, Human)	WB, Chemotaxis	Human
Rahman MS, Thomas P. Molecular cloning and characterization of two ARNT (ARNT-1 and ARNT-2) genes in Atlantic croaker and their expression during coexposure to hypoxia and PCB77. Environ. Toxicol. 2018-10-18 [PMID: 30334616] (IF/IHC, Fish)	IF/IHC	Fish
Rodrigues P, Patel SA, Harewood L et al. NF-kB-Dependent Lymphoid Enhancer Co-option Promotes Renal Carcinoma Metastasis Cancer Discov 2018-06-06 [PMID: 29875134] (Human)		Human
Kim YC, Seok S, Byun S, Kong B. AhR and SHP regulate phosphatidylcholine and S-adenosylmethionine levels in the one-carbon cycle. Nat Commun. 2018-02-07 [PMID: 29416063] (Mouse)		Mouse
Tiana M, Acosta-Iborra B, Puente-Santamaria L et al. The SIN3A histone deacetylase complex is required for a complete transcriptional response to hypoxia Nucleic Acids Res. 2018-01-09 [PMID: 29059365] (Chemotaxis, Human)	Chemotaxis	Human
Kobayashi M, Morinibu A, Koyasu S et al. A circadian clock gene, PER2, activates HIF-1 as an effector molecule for recruitment of HIF-1a to promoter regions of its downstream genes. FEBS J. 2017-09-30 [PMID: 28963769] (WB, Human)	WB	Human
Grampp S, Schmid V, Salama R et al. Multiple renal cancer susceptibility polymorphisms modulate the HIF pathway PLoS Genet. 2017-07-16 [PMID: 28715484] (Chemotaxis, Human)	Chemotaxis	Human
Grampp S, Platt JL, Lauer V et al. Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer. Nat Commun 2016-10-24 [PMID: 27774982] (Chemotaxis, Human)	Chemotaxis	Human
Kraus A, Grampp S, Goppelt-Struebe M et al. P2Y2R is a direct target of HIF-1alpha and mediates secretion-dependent cyst growth of renal cyst-forming epithelial cells. Purinergic Signal. 2016-08-26 [PMID: 27565965] (Chemotaxis, Human, Mouse)	Chemotaxis	Human, Mouse
Platt JL, Salama R, Smythies J et al. Capture-C reveals preformed chromatin interactions between HIF-binding sites and distant promoters. EMBO Rep. [PMID: 27506891] (Chemotaxis, Human)	Chemotaxis	Human
Salama R, Masson N, Simpson P et al. Heterogeneous Effects of Direct Hypoxia Pathway Activation in Kidney Cancer. PLoS ONE. 2015-08-12 [PMID: 26262842] (Chemotaxis, Human)	Chemotaxis	Human
Long F, Si L, Long X et al. 2ME2 increase radiation-induced apoptosis of keloid fibroblasts by targeting HIF-1a in vitro. Australas J Dermatol. 2015-04-15 [PMID: 25872882] (WB, Human)	WB	Human
Dela Cruz J A D, Schmidt-Kastner R, Stevens J A A et al. Differential distribution of hypoxia-inducible factor 1-beta (ARNT or ARNT2) in mouse substantia nigra and ventral tegmental area. J Chem Neuroanat. 2014-07-10 [PMID: 25017895] (Mouse)		Mouse
Wong WJ, Richardson T, Seykora JT et al. Hypoxia-inducible factors regulate filaggrin expression and epidermal barrier function. J Invest Dermatol 2015-02-01 [PMID: 24999590] (Mouse)		Mouse
Rataj F, Moller FJ, Jahne M et al. Progesterone, as well as 17beta-estradiol, is important for regulating AHR battery homoeostasis in the rat uterus. Arch. Toxicol. 2014-04-29 [PMID: 24777823] (IHC-P, Rat)	IHC-P	Rat
Zhu J, Jiang X, Chehab FF. FoxO4 Interacts with the Sterol Regulatory Factor SREBP2 and the Hypoxia Inducible Factor HIF2A at the CYP51 Promoter. J Lipid Res 2013-12-18 [PMID: 24353279] (WB, Mouse)	WB	Mouse
Sena JA, Wang L, Hu CJ. BRG1 and BRM chromatin-remodeling complexes regulate the hypoxia response by acting as coactivators for a subset of hypoxia-inducible transcription factor target genes. Mol Cell Biol 2013-10-01 [PMID: 23897427] (IP)	IP
Pawlus MR, Wang L, Hu CJ. STAT3 and HIF1alpha cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells. Oncogene 2013-04-22 [PMID: 23604114] (Chemotaxis, Human)	Chemotaxis	Human
Grelli KN, Palubinsky AM, Kale AC et al. Alteration of Isocitrate Dehydrogenase Following Acute Ischemic Injury as a Means to Improve Cellular Energetic Status in Neuroadaptation CNS Neurol Disord Drug Targets. 2014-08-31 [PMID: 23469839] (WB, ICC/IF, Rat)	WB, ICC/IF	Rat
Schito L, Rey S, Tafani M et al. Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells Proc Natl Acad Sci U S A 2012-10-02 [PMID: 23012449] (Chemotaxis, Human)	Chemotaxis	Human
Lo R, Matthews J. High-resolution genome-wide mapping of AHR and ARNT binding sites by ChIP-Seq Toxicol Sci 2012-08-17 [PMID: 22903824] (Chemotaxis, Human)	Chemotaxis	Human
Schodel J, Bardella C, Sciesielski LK et al. Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression Nat Genet 2012-03-11 [PMID: 22406644] (Chemotaxis, Human)	Chemotaxis	Human
Koizume S, Ito S, Miyagi E et al. HIF2 alpha-Sp1 interaction mediates a deacetylation-dependent FVII-gene activation under hypoxic conditions in ovarian cancer cells Nucleic Acids Res 2012-03-08 [PMID: 22402494] (WB, Chemotaxis, Human)	WB, Chemotaxis	Human
Huang B, Deora AB, He K-L et al. Hypoxia-inducible factor-1 drives annexin A2 system-mediated perivascular fibrin clearance in oxygen-induced retinopathy in mice. Blood. 2011-07-25 [PMID: 21788340] (IB, Mouse)	IB	Mouse
Jantsch J, Wiese M, Schodel J et al. Toll-like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia-inducible factor 1{alpha} (HIF1A) and result in differential HIF1A-dependent gene expression. J Leukoc Biol. 2011-06-17 [PMID: 21685248] (Chemotaxis, IB)	Chemotaxis, IB
Stejskalova L, Vecerova L, Perez LM et al. Aryl hydrocarbon receptor and aryl hydrocarbon nuclear translocator expression in human and rat placentas and transcription activity in human trophoblast cultures. Toxicol Sci;123(1):26-36. 2011-09-01 [PMID: 21666223] (IHC-P, Rat, Human)	IHC-P	Rat, Human
Lin Q, Cong X, Yun Z. Differential hypoxic regulation of hypoxia-inducible factors 1alpha and 2alpha Mol Cancer Res 2011-06-01 [PMID: 21571835] (WB, Human)	WB	Human
Schodel J, Oikonomopoulos S, Ragoussis J et al. High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq. Blood. 2011-03-29 [PMID: 21447827] (Chemotaxis, Human)	Chemotaxis	Human
Glover LE, Irizarry K, Scully M et al. IFN-gamma attenuates hypoxia-inducible factor (HIF) activity in intestinal epithelial cells through transcriptional repression of HIF-1beta. J Immunol;186(3):1790-1798. 2011-02-01 [PMID: 21199896] (WB, Human)	WB	Human
Gimm T, Wiese M, Teschemacher B et al. Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1 FASEB J 2010-11-01 [PMID: 20624928] (Chemotaxis, Human)	Chemotaxis	Human
Chung CY, Koprich JB, Siddiqi H et al. Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV alpha-synucleinopathy. J Neurosci 2009-03-01 [PMID: 19295143] (WB, Rat)	WB	Rat
Alam H, Weck J, Maizels E et al. Role of the Phosphatidylinositol-3-Kinase Extracellular Regulated Kinase Pathways in the Induction of Hypoxia-Inducible Factor (HIF)-1 Activity the HIF-1 Target Vascular Endothelial Growth Factor in Ovarian Granulosa Cells in Response to Follicle-Stimulating Hormone. Endocrinology;150(2):915-928. 2009-01-01 [PMID: 18845636] (WB, Rat)	WB	Rat
Groenman F, Rutter M, Caniggia I et al. Hypoxia-inducible factors in the first trimester human lung. J Histochem Cytochem 2007-04-01 [PMID: 17189520] (IF/IHC, Human)	IF/IHC	Human
Khan Z, Michalopoulos GK, Stolz DB. Peroxisomal localization of hypoxia-inducible factors and hypoxia-inducible factor regulatory hydroxylases in primary rat hepatocytes exposed to hypoxia-reoxygenation. Am J Pathol 2006-10-01 [PMID: 17003483] (ICC/IF, Rat)	ICC/IF	Rat
Franco M, Man S, Chen L et al. Targeted anti-vascular endothelial growth factor receptor-2 therapy leads to short-term and long-term impairment of vascular function and increase in tumor hypoxia. Cancer Res 2006-04-01 [PMID: 16585189] (WB)	WB
Malm C, Sjodin TL, Sjoberg B et al. Leukocytes, cytokines, growth factors and hormones in human skeletal muscle and blood after uphill or downhill running. J Physiol 2004-05-01 [PMID: 14766942] (IF/IHC, Human)	IF/IHC	Human
Palladino MA, Powell JD, Korah N, Hermo L. Expression and localization of hypoxia-inducible factor-1 subunits in the adult rat epididymis. Biol Reprod 2004-04-01 [PMID: 14668208] (WB, Rat)	WB	Rat
Danet GH, Pan Y, Luongo JL et al. Expansion of human SCID-repopulating cells under hypoxic conditions. J Clin Invest 2003-07-01 [PMID: 12840067] (WB)	WB
Powell JD, Elshtein R, Forest DJ, Palladino MA. Stimulation of hypoxia-inducible factor-1 alpha (HIF-1alpha) protein in the adult rat testis following ischemic injury occurs without an increase in HIF-1alpha messenger RNA expression. Biol Reprod 2002-09-01 [PMID: 12193413] (WB, Rat)	WB	Rat
Almer, LA et al. Normoxic stabilization of hypoxia-inducible factor-1 expression and activity: redox-dependent effect of nitrogen oxides. Mol Pharmacol;58(6):1197-203. 2000-12-01 [PMID: 11093754] (WB, Rat, Bovine)	WB	Rat, Bovine
Sulentic CE, Holsapple MP, Kaminski NE. Putative link between transcriptional regulation of IgM expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin and the aryl hydrocarbon receptor/dioxin-responsive enhancer signaling pathway. J Pharmacol Exp Ther 2000-11-01 [PMID: 11046109] (EMSA, Mouse)	EMSA	Mouse
Show All 73 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: Verified Customer	ChIP	Human	07/05/2019	View Summary Application Chromatin Immunoprecipitation Sample Tested Human cancer cell lines Species Human Lot C-10
Enlarge	5 reviewed by: Verified Customer	ChIP	Human	12/02/2018	View Summary Application Chromatin Immunoprecipitation Sample Tested MCF7 Species Human Lot C-7
Enlarge	5 reviewed by: Verified Customer	ChIP	Human	07/07/2016	View Summary Application Chromatin Immunoprecipitation Sample Tested U2OS Species Human

Array NB100-110

• ARNT/HIF-1 beta Antibodies
• ARNT/HIF-1 beta Antibody Pack
• ARNT/HIF-1 beta ELISA Kits
• ARNT/HIF-1 beta Lysate
• ARNT/HIF-1 beta Proteins