AHR Antibody

Aryl hydrocarbon Receptor (AhR) is a ligand-activated transcriptional activator that binds to XRE promoter region of its target genes and has been established to activate phase I/II xenobiotic biotransformation enzyme genes. AhR binds MYBBP1A and its efficient DNA binding requires dimerization with another bHLH proteinsuch as ARNT. Besides interacting with NEDD8 and IVNS1ABP, AhR also interacts with coactivators including SRC-1, RIP140 and NOCA7, and with the corepressor SMRT. AhR localize to cytoplasm and upon binding with ligand followed by interaction with a HSP90, it translocates to the nucleus. AhR has been shown to be induced or repressed by TGFB1 as well as dioxin in a cell-type specific fashion, whereas cAMP, retinoic acid, TPA (12-O-tetradecanoyl phorbol-13 acetate) have been shown to exert repressive effects on AhR. As a member of bHLH-PAS (basic helix-loop-helix Per/ARNT/Sim) family, AhR has been implicated in physiological processes such as circadian cycle, neurogenesis, organs development and regulation of cell-cycle as well as the alternative signaling pathways (independently of exposure to xenobiotics). AhR-null mice exhibit infertility, liver abnormalities and cardiovascular problems such as a defective closure of the ductus venosus, indicative of the implication of the AhR in various developmental processes.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 8 applications: Chemotaxis, EMSA, GS, ICC/IF, IF, IF/IHC, IHC-P, WB.

Showing Publications 1 - 10 of 16. Show All 16 Publications. Collapse Publications.

Publications using NB100-128	Applications	Species
Urzì O, Cafora M, Ganji N et al. Lemon-derived nanovesicles achieve antioxidant and anti-inflammatory effects activating the AhR/Nrf2 signaling pathway iScience 2023-07-01 [PMID: 37426343] (WB, Human)	WB	Human
Jiang J, Zhu J, Liu Q et al. Role of DNA methylation-related chromatin remodeling in aryl hydrocarbon receptor-dependent regulation of T-2 toxin highly inducible Cytochrome P450 1A4 gene FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021-05-01 [PMID: 33788981]
Liu Q, Wen J, Zhu J et al. Aromatic hydrocarbon receptor regulates chicken cytochrome P450 1A5 transcription: A novel insight into T-2 toxin-induced gene expression and cytotoxicity in LMH cells Biochem. Pharmacol. 2019-07-25 [PMID: 31351871] (WB)	WB
Vogel CF, Khan EM, Leung PS et al. Cross-talk between Aryl Hydrocarbon Receptor and the inflammatory response: a Role for NF-kB. J Biol Chem. 2013-12-03 [PMID: 24302727] (WB, Human, Mouse)	WB	Human, Mouse
Vogel CF, Wu D, Goth SR et al. Aryl hydrocarbon receptor signaling regulates NF-kB RelB activation during dendritic-cell differentiation. Immunol Cell Biol. 2013-09-03 [PMID: 23999131] (EMSA, WB, Mouse)	EMSA, WB	Mouse
Vogel CF, Li W, Wu D et al. Interaction of aryl hydrocarbon receptor and NF-kappaB subunit RelB in breast cancer is associated with interleukin-8 overexpression. Arch Biochem Biophys 2011-08-01 [PMID: 21640702] (IF/IHC, Human)	IF/IHC	Human
Dabir P et al. Aryl hydrocarbon receptor is activated by glucose and regulates the thrombospondin-1 gene promoter in endothelial cells. Circ Res;102(12):1558-65. 2008-06-20 [PMID: 18515748] (GS, IF, Human, Rat)	GS, IF	Human, Rat
Fukuda I, Nishiumi S, Yabushita Y et al. A new southwestern chemistry-based ELISA for detection of aryl hydrocarbon receptor transformation: application to the screening of its receptor agonists and antagonists. J Immunol Methods 2004-04-01 [PMID: 15099767] (Human)		Human
Fisher, M et al. Combined screening of thymocytes using apoptosis-specific cDNA array and promoter analysis yields novel gene targets mediating TCDD-induced toxicity. Toxicol Sci;78(1):116-24. 2004-03-01 [PMID: 14718646] (Chemotaxis, Mouse)	Chemotaxis	Mouse
Tsuchiya, Y et al. Critical enhancer region to which AhR/ARNT and Sp1 bind in the human CYP1B1 gene. J Biochem;133(5):583-92. 2003-05-01 [PMID: 12801909] (GS, Human)	GS	Human
Minsavage, GD et al. Mutational analysis of the mouse aryl hydrocarbon receptor tyrosine residues necessary for recognition of dioxin response elements. Arch Biochem Biophys;412(1):95-105. 2003-04-01 [PMID: 12646272]
Hayashibara, T et al. Possible involvement of aryl hydrocarbon receptor (AhR) in adult T-cell leukemia (ATL) leukemogenesis: constitutive activation of AhR in ATL. Biochem Biophys Res Commun;300(1):128-34. 2003-01-03 [PMID: 12480531]
Chan, WK et al. Baculovirus expression of the Ah receptor and Ah receptor nuclear translocater. Evidence for additional dioxin responsive element-binding species and factors required for signaling. J Biol Chem;269(42):26464-71. 1994-10-21 [PMID: 7929368]
Poland, A, Glover, E, Bradfield, CA. Characterization of polyclonal antibodies to the Ah receptor prepared by immunization with a synthetic peptide hapten. Mol Pharmacol;39(1):20-6. 1991-01-01 [PMID: 1846218]
Pambianchi E, Hagenberg Z, Pecorelli A Et al. Alaskan Bog Blueberry (Vaccinium uliginosum) Extract as an Innovative Topical Approach to Prevent UV-Induced Skin Damage Cosmetics 2021-11-27 (IHC-P, Human)	IHC-P	Human
Du J, Li S, Gu Y et al. Prevotella histicola inhibits neuroinflammation-induced activation of the Toll-like receptor 4 pathway by promoting the release of interleukin 10 from FoxP3+ Treg cells Research Square 2022-06-21 (IF/IHC, ICC/IF, Human)	IF/IHC, ICC/IF	Human
Show All 16 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	WB	Human	04/02/2014	View Summary Application Western Blot Sample Tested U937 cell nuclear protein Species Human Lot 12802

Array NB100-128

• AHR Antibodies
• AHR ELISA Kits
• AHR Lysate
• AHR Proteins