CAR/NR1I3 Antibody (N4111) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CAR, (MB67; NR1I3) is a 40 kDa member of the NR1 subfamily of the nuclear hormone receptor family. CAR is predominantly expressed in the liver and forms a heterodimer with RXR. The CAR/RXR heterodimer activates retinoic acid, xenobiotic and phenobarbital response elements. There are two isoforms of the CAR nuclear hormone receptor. Each contains a DNA-binding hinge and dimerization domain. One is full-length at 352 amino acids while the other shows a 4 amino acid truncation at the extreme C-terminus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 4 confirmed species: Human, Mouse, Primate - Chlorocebus aethiops (African Green Monkey), Rabbit.

We have publications tested in 5 applications: ChIP, ICC, IHC, IHC-P, Western Blot.

Showing Publications 1 - 8 of 8.

Publications using PP-N4111-00	Applications	Species
MN Bwayi, E Garcia-Mal, SC Chai, B Xie, S Chodankar, AD Huber, J Wu, K Annu, WC Wright, HM Lee, J Seetharama, J Wang, CD Buchman, J Peng, T Chen Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation Nucleic Acids Research, 2022-04-08;0(0):. 2022-04-08 [PMID: 35212371] (Western Blot, Human)	Western Blot	Human
C Pan, J Kang, JS Hwang, J Li, AC Boese, X Wang, L Yang, TJ Boggon, GZ Chen, NF Saba, DM Shin, KR Magliocca, L Jin, S Kang Cisplatin-mediated activation of glucocorticoid receptor induces platinum resistance via MAST1 Nature Communications, 2021-08-16;12(1):4960. 2021-08-16 [PMID: 34400618] (ICC, IHC, Human)	ICC, IHC	Human
Impaired Hepatic Adaptation to Chronic Cholestasis induced by Primary Sclerosing Cholangitis Sci Rep, 2016-12-23;6(0):39573. 2016-12-23 [PMID: 28008998] (Western Blot, Human)	Western Blot	Human
Chen , Tao, Laurenzana , Elizabet, Coslo , Denise M, Chen , Fengming, Omiecinski , Curtis J Proteasomal interaction as a critical activity modulator of the human constitutive androstane receptor. Biochem J, 2014-02-15;458(1):95-107. 2014-02-15 [PMID: 24224465] (Western Blot, Primate - Chlorocebus aethiops (African Green Monkey))	Western Blot	Primate - Chlorocebus aethiops (African Green Monkey)
Regulation of the human hydroxysteroid sulfotransferase (SULT2A1) by RORα and RORγ and its potential relevance to human liver diseases. Mol Endocrinol, 2012-12-04;27(1):106-15. 2012-12-04 [PMID: 23211525] (ChIP, Human)	ChIP	Human
Mebis L, Eerdekens A, Guiza F, Princen L, Derde S, Vanwijngaerden YM, Vanhorebeek I, Darras VM, Van den Berghe G, Langouche L Contribution of nutritional deficit to the pathogenesis of the nonthyroidal illness syndrome in critical illness: a rabbit model study. Endocrinology, 2011-12-13;153(2):973-84. 2011-12-13 [PMID: 22166982] (IHC-P, Rabbit)	IHC-P	Rabbit
Sueyoshi T, Green WD, Vinal K, Woodrum TS, Moore R, Negishi M Garlic Extract Diallyl Sulfide (DAS) Activates Nuclear Receptor CAR to Induce the Sult1e1 Gene in Mouse Liver. PLoS ONE, 2011-06-15;6(6):e21229. 2011-06-15 [PMID: 21698271] (Western Blot, Mouse)	Western Blot	Mouse
Surapureddi S, Rana R, Reddy JK, Goldstein JA Nuclear receptor coactivator 6 mediates the synergistic activation of human cytochrome P-450 2C9 by the constitutive androstane receptor and hepatic nuclear factor-4alpha. Mol. Pharmacol., 2008-06-13;74(3):913-23. 2008-06-13 [PMID: 18552123] (ChIP, Western Blot, Human)	ChIP, Western Blot	Human

Array PP-N4111-00

• CAR/NR1I3 Antibodies
• CAR/NR1I3 Lysates