CAR/NR1I3 Products

Description

NR1I3 encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene.

Bioinformatics

Uniprot	NP_001070939 Human NP_001070948.1 Human NP_001070949 Human NP_001070950 Human NP_005113 Human NP_005113.1 Human Q14994 Human
Product By Gene ID	9970
Alternate Names	CARCAR1 Constitutive activator of retinoid response constitutive active receptor Constitutive active response Constitutive androstane receptor MB67 MGC150433 MGC97144 MGC97209 nuclear receptor subfamily 1 group I member 3 nuclear receptor subfamily 1, group I, member 3 orphan nuclear hormone receptor Orphan nuclear receptor MB67

Research Areas for CAR/NR1I3

Find related products by research area and learn more about each of the different research areas below.

Lipid and Metabolism