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APLP-2 Antibody [Unconjugated]

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

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Catalog# & Formulation Size Price
Carrier Free
AF3685-SP
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APLP-2 Antibody [Unconjugated] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse APLP-2
Leu37-Ser624
Accession # AAH52396.2
Specificity
Detects mouse APLP-2 in direct ELISAs and Western blots. In direct ELISAs, approximately 50% cross-reactivity with recombinant human (rh) APLP-2 is observed and less than 1% cross-reactivity with rhAPLP-1 and recombinant mouse APLP-1 is observed.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
APLP2
Purity Statement
Antigen Affinity-purified
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Applications/Dilutions

Dilutions
  • Western Blot 0.1 ug/mL
Publications
Read Publication using
AF3685 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for APLP-2 Antibody [Unconjugated]

  • amyloid beta (A4) precursor-like protein 2
  • amyloid precursor protein homolog HSD-2
  • Amyloid protein homolog
  • amyloid-like protein 2
  • APLP2
  • APLP-2
  • APPH
  • APPHCDEI box-binding protein
  • APPL2
  • CDEBP
  • WALPLP2
  • YWK-II

Background

Mouse APLP-2 is a 120-170 kDa (695 aa) member of the APP family of type I transmembrane (TM) proteins. Its 595 aa extracellular region has multiple domains, including an N-terminal Cys-rich domain, an Asp/Glu-rich acidic region, and a membrane proximal linker region that contains a GAG attachment site. Several alternatively spliced APLP-2 isoforms have been reported. APLP-2 is proteolytically cleaved by MMPs and secretases and forms both homodimers and heterodimers with APP and APLP-1. Over the range used as immunogen, mouse APLP-2 shares 97% and 91% aa sequence identity with rat and human ALPL-2, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for APLP-2 Antibody (AF3685)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: Bioassay, IHC.


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Bioinformatics

Gene Symbol APLP2
Uniprot